This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011].
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Sambi, Chow, Whiteley, Li, Chua, Raileanu, Rogers: "Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors." in: Stem cell reviews, (2017) (PubMed).
Calcagnì, Kors, Verschuren, De Cegli, Zampelli, Nusco, Confalonieri, Bertalot, Pece, Settembre, Malouf, Leemans, de Heer, Salvatore, Peters, Di Fiore, Ballabio: "Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling." in: eLife, Vol. 5, (2016) (PubMed).
Thedieck, Kalbacher, Kratzer, Lammers, Stevanovic, Klein: "alpha B-crystallin is a cytoplasmic interaction partner of the kidney-specific cadherin-16." in: Journal of molecular biology, Vol. 378, Issue 1, pp. 145-53, (2008) (PubMed).
Synonyms and alternative names related to Cadherin-16