CACNB4 Products
(Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))
Categories
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
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Featured CACNB4 Categories
CACNB4 Antibodies
High quality antibodies with extensive validation data.
CACNB4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CACNB4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, ICC, IHC (p)
Validations
- (4)
Cat. No.
ABIN2854649
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
- (4)
Cat. No.
ABIN2774681
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7175600
Quantity
100 μg
Datasheet
Datasheet
Recommended CACNB4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6213229
Quantity
96 tests
Datasheet
Datasheet
Recommended CACNB4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1347838
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1347836
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3090330
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our CACNB4 products
: "Nerve injury induces a Gem-GTPase-dependent downregulation of P/Q-type Ca2+ channels contributing to neurite plasticity in dorsal root ganglion neurons." in: Pflügers Archiv : European journal of physiology, Vol. 467, Issue 2, pp. 351-66, (2015) (PubMed).: "Differential neuronal targeting of a new and two known calcium channel ?4 subunit splice variants correlates with their regulation of gene expression." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 4, pp. 1446-61, (2014) (PubMed).
: "The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 37, pp. 12289-303, (2014) (PubMed).
: "CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-? plaques in an Alzheimer's disease mouse model." in: Journal of Alzheimer's disease : JAD, Vol. 37, Issue 2, pp. 439-51, (2013) (PubMed).
: "Up-regulation of Cav?3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain." in: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 6002-13, (2012) (PubMed).
: "Regional expression and subcellular localization of the voltage-gated calcium channel ? subunits in the developing mouse brain." in: Journal of neurochemistry, Vol. 122, Issue 6, pp. 1095-107, (2012) (PubMed).
: "RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction." in: Cell, Vol. 144, Issue 2, pp. 282-95, (2011) (PubMed).
: "CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation." in: Journal of neurochemistry, Vol. 112, Issue 1, pp. 150-61, (2010) (PubMed).
: "Reciprocal interactions regulate targeting of calcium channel beta subunits and membrane expression of alpha1 subunits in cultured hippocampal neurons." in: The Journal of biological chemistry, Vol. 285, Issue 8, pp. 5776-91, (2010) (PubMed).
: "Differential modulation of N-type calcium channels by micro-opioid receptors in oxytocinergic versus vasopressinergic neurohypophysial terminals." in: Journal of cellular physiology, Vol. 225, Issue 1, pp. 276-88, (2010) (PubMed).
Synonyms and alternative names related to CACNB4
calcium voltage-gated channel auxiliary subunit beta 4 (CACNB4), calcium channel, voltage-dependent, beta 4 subunit (Cacnb4), calcium voltage-gated channel auxiliary subunit beta 4 (Cacnb4), calcium channel, voltage-dependent, beta 4 subunit (cacnb4.1), calcium channel, voltage-dependent, beta 4 subunit (cacnb4), calcium channel, voltage-dependent, beta 4a subunit (cacnb4a), 3110038O15Rik, CAB4, CACNB4, cacnb4.2, CACNLB4, Cchb4, EA5, EIG9, EJM, EJM4, EJM6, lethargic, lhProtein level used designations for CACNB4
- calcium channel voltage-dependent subunit beta 4
- dihydropyridine-sensitive L-type, calcium channel beta-4 subunit
- voltage-dependent L-type calcium channel subunit beta-4
- CAB4
- calcium channel beta 4 subunit
- voltage-dependent calcium channel beta 4 subunit
- calcium channel, voltage-dependent, beta 4 subunit
- voltage-gated calcium channel beta 4.1 subunit
- voltage-dependent L-type calcium channel subunit beta-4-like
- CAB4a
- voltage-dependent calcium channel beta 4a subunit
- voltage-gated calcium channel beta-4.2
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