CACNA2D1 Products
(Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1))
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This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
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CACNA2D1 Antibodies
High quality antibodies with extensive validation data.
CACNA2D1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CACNA2D1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7175577
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS
Validations
- (2)
Cat. No.
ABIN652644
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN190770
Quantity
100 μg
Datasheet
Datasheet
Recommended CACNA2D1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN5709179
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CACNA2D1 products
: "Calcium Channel α2δ1 Subunit Mediates Secondary Orofacial Hyperalgesia Through PKC-TRPA1/Gap Junction Signaling." in: The journal of pain : official journal of the American Pain Society, (2019) (PubMed).: "Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility." in: Nature communications, Vol. 8, Issue 1, pp. 1755, (2018) (PubMed).
: "Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α(2)δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity." in: Neuroscience bulletin, Vol. 32, Issue 1, pp. 41-50, (2016) (PubMed).
: "Prognostic and clinicopathological significance of Cacna2d1 expression in epithelial ovarian cancers: a retrospective study." in: American journal of cancer research, Vol. 6, Issue 9, pp. 2088-2097, (2016) (PubMed).
: "Identification of Glycosylation Sites Essential for Surface Expression of the CaVα2δ1 Subunit and Modulation of the Cardiac CaV1.2 Channel Activity." in: The Journal of biological chemistry, Vol. 291, Issue 9, pp. 4826-43, (2016) (PubMed).
: "PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells." in: Nature communications, Vol. 6, pp. 8271, (2015) (PubMed).
: "Ca(V)1.2 channel N-terminal splice variants modulate functional surface expression in resistance size artery smooth muscle cells." in: The Journal of biological chemistry, Vol. 286, Issue 17, pp. 15058-66, (2011) (PubMed).
: "Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes." in: American journal of physiology. Heart and circulatory physiology, Vol. 300, Issue 3, pp. H978-88, (2011) (PubMed).
: "A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. ..." in: Cell, Vol. 143, Issue 4, pp. 628-38, (2010) (PubMed).
: "Functional vitamin D receptor (VDR) in the t-tubules of cardiac myocytes: VDR knockout cardiomyocyte contractility." in: Endocrinology, Vol. 149, Issue 2, pp. 558-64, (2008) (PubMed).
Synonyms and alternative names related to CACNA2D1
calcium voltage-gated channel auxiliary subunit alpha2delta 1 (CACNA2D1), calcium channel, voltage-dependent, alpha 2/delta subunit 1 (cacna2d1), calcium voltage-gated channel auxiliary subunit alpha2delta 1 (cacna2d1), calcium voltage-gated channel auxiliary subunit alpha2delta 1 (Cacna2d1), calcium channel, voltage-dependent, alpha2/delta subunit 1 (Cacna2d1), Ca(v)alpha2delta1, CACNA2, Cacna2, CACNA2D1, CACNL2A, CCHL2A, Cchl2a, CCHLA2, DHSCCA, DKFZp469K2211Protein level used designations for CACNA2D1
- calcium channel, voltage-dependent, alpha 2/delta subunit 1
- voltage-dependent calcium channel subunit alpha-2/delta-1-like
- calcium channel, L type, alpha 2 polypeptide
- dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit
- voltage-dependent calcium channel subunit alpha-2/delta-1
- voltage-gated calcium channel subunit alpha-2/delta-1
- dihydropryridine-sensitive calcium channel alpha-2 subunit
- dihydropyridine-sensitive calcium channel alpha 2
- Calcium channel subunit alpha 2 delta (dihydropyridine - sensitive L-type)
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