BTRC Products
(beta-Transducin Repeat Containing (BTRC))
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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class\; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012].
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Featured BTRC Categories
BTRC Antibodies
High quality antibodies with extensive validation data.
BTRC ELISA Kits
Reliable ELISA kits for a wide range of species.
BTRC Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended BTRC Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS
Validations
- (7)
Cat. No.
ABIN5611131
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN3022334
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p)
Validations
- (4)
Cat. No.
ABIN655814
Quantity
400 μL
Datasheet
Datasheet
Recommended BTRC ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1743134
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Sheep
Analytical Method
Validations
Cat. No.
ABIN1774039
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Dog
Analytical Method
Validations
Cat. No.
ABIN1769143
Quantity
96 tests
Datasheet
Datasheet
Recommended BTRC Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346979
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3092532
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3135065
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our BTRC products
: "REST reduction is essential for hypoxia-induced neuroendocrine differentiation of prostate cancer cells by activating autophagy signaling." in: Oncotarget, Vol. 7, Issue 18, pp. 26137-51, (2018) (PubMed).: "Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1." in: The Journal of biological chemistry, Vol. 279, Issue 15, pp. 14484-7, (2004) (PubMed).
: "Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition." in: Nature cell biology, Vol. 6, Issue 10, pp. 931-40, (2004) (PubMed).
: "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage." in: Nature, Vol. 426, Issue 6962, pp. 87-91, (2003) (PubMed).
: "Identification of the receptor component of the IkappaBalpha-ubiquitin ligase." in: Nature, Vol. 396, Issue 6711, pp. 590-4, (1999) (PubMed).
: "A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif." in: Molecular cell, Vol. 1, Issue 4, pp. 565-74, (1998) (PubMed).
Synonyms and alternative names related to BTRC
beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC), beta-transducin repeat containing E3 ubiquitin protein ligase (btrc), beta-transducin repeat containing (btrc), beta-TrCP (LOC100634006), beta-transducin repeat containing E3 ubiquitin protein ligase (Btrc), beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog (btrc.S), beta-transducin repeat containing protein (Btrc), b-TrCP, Beta-TrCP, beta-TrCP, BETA-TRCP, beta-TrCP1, Beta-Trcp1, betaTrCP, BTRC, btrc, btrc-a, btrcp, bTrCP, btrcp1, bTrCP1, fbw1a, FBW1A, Fbw1a, fbxw1, FBXW1, fbxw1a, FBXW1A, fwd1, FWD1, HOS, mKIAA4123, SlimbProtein level used designations for BTRC
- beta-transducin repeat containing
- beta-transducin repeat containing protein
- F-box/WD repeat-containing protein 1A
- f-box/WD repeat-containing protein 1A-like
- E3RSIkappaB
- F-box and WD repeats protein beta-TrCP
- F-box and WD-repeat protein 1B
- beta-TrCP1
- epididymis tissue protein Li 2a
- pIkappaBalpha-E3 receptor subunit
- beta-TrCP
- beta-transducin repeat-containing protein
- SCF b-TRCP
- beta-TrCP protein E3RS-IkappaB
- mE3RS-IkappaB
- pIkappaB-E3 receptor subunit
- ubiquitin ligase FWD1
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