BTBD12 Products
(BTB (POZ) Domain Containing 12 (BTBD12))
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This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011].
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Featured BTBD12 Categories
BTBD12 Antibodies
High quality antibodies with extensive validation data.
Recommended BTBD12 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
- (1)
Cat. No.
ABIN529697
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human, Monkey
Application
WB
Validations
- (1)
Cat. No.
ABIN6746693
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IP, IHC (p), IHC, IF
Validations
- (1)
Cat. No.
ABIN2571811
Quantity
50 μL
Datasheet
Datasheet
Recommended BTBD12 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Schizosaccharomyces pombe
Source
Yeast
Validations
Cat. No.
ABIN1652594
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our BTBD12 products
: "Expression of Telomere-Associated Proteins is Interdependent to Stabilize Native Telomere Structure and Telomere Dysfunction by G-Quadruplex Ligand Causes TERRA Upregulation." in: Cell biochemistry and biophysics, (2017) (PubMed).: "Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment." in: mBio, Vol. 7, Issue 5, (2016) (PubMed).
: "SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres." in: Cell reports, Vol. 4, Issue 5, pp. 861-9, (2013) (PubMed).
: "The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP/SLX4." in: Human molecular genetics, Vol. 21, Issue 22, pp. 4948-56, (2012) (PubMed).
: "Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis." in: PLoS genetics, Vol. 7, Issue 6, pp. e1002094, (2011) (PubMed).
: "Mutations of the SLX4 gene in Fanconi anemia." in: Nature genetics, Vol. 43, Issue 2, pp. 142-6, (2011) (PubMed).
Synonyms and alternative names related to BTBD12
SLX4 structure-specific endonuclease subunit (Slx4), SLX4 structure-specific endonuclease subunit (SLX4), SLX4 structure-specific endonuclease subunit homolog (SLX4), SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) (Slx4), AI256635, AI426760, Btbd12, BTBD12, D16Bwg1016e, FANCP, MUS312, RGD1566009Protein level used designations for BTBD12
- BTB (POZ) domain containing 12
- SLX4 structure-specific endonuclease subunit homolog
- structure-specific endonuclease subunit SLX4
- BTB/POZ domain-containing protein 12
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