BRCC3 Products
(BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
Categories
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011].
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Featured BRCC3 Categories
BRCC3 Antibodies
High quality antibodies with extensive validation data.
BRCC3 ELISA Kits
Reliable ELISA kits for a wide range of species.
BRCC3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended BRCC3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (4)
Cat. No.
ABIN7158679
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7158678
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IHC (p)
Validations
- (3)
Cat. No.
ABIN462274
Quantity
50 μL
Datasheet
Datasheet
Recommended BRCC3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6954187
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN2945768
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5652335
Quantity
96 tests
Datasheet
Datasheet
Recommended BRCC3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346851
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7414093
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN5709149
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our BRCC3 products
: "SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy." in: PLoS pathogens, Vol. 14, Issue 5, pp. e1007071, (2018) (PubMed).: "miR-3940-5p associated with genetic damage in workers exposed to hexavalent chromium." in: Toxicology letters, Vol. 229, Issue 1, pp. 319-26, (2014) (PubMed).
: "BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation." in: Cancer research, Vol. 66, Issue 10, pp. 5039-46, (2006) (PubMed).
: "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair." in: Molecular cell, Vol. 12, Issue 5, pp. 1087-99, (2003) (PubMed).
Synonyms and alternative names related to BRCC3
BRCA1/BRCA2-containing complex subunit 3 (BRCC3), DEP domain containing 1B (depdc1b), BRCA1/BRCA2-containing complex subunit 3 (brcc3), BRCA1/BRCA2-containing complex, subunit 3 (Brcc3), BRCA1/BRCA2-containing complex subunit 3 L homeolog (brcc3.L), BRCC3, brcc3, BRCC36, brcc36, C6.1A, CXorf53, xtp1Protein level used designations for BRCC3
- BRCA1/BRCA2-containing complex, subunit 3
- c6.1A
- BRCA1-A complex subunit BRCC36
- BRCA1/BRCA2-containing complex subunit 3
- BRCA1/BRCA2-containing complex subunit 36
- BRISC complex subunit BRCC36
- lys-63-specific deubiquitinase BRCC36
- 6.1A protein
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