BRCA2 Products
(Breast Cancer 2, Early Onset (BRCA2))
Categories
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008].
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Featured BRCA2 Categories
BRCA2 Antibodies
High quality antibodies with extensive validation data.
BRCA2 ELISA Kits
Reliable ELISA kits for a wide range of species.
BRCA2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended BRCA2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p)
Validations
- (2)
- (1)
Cat. No.
ABIN673434
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, IHC, IF
Validations
- (7)
Cat. No.
ABIN7234156
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7433543
Quantity
100 μL
Datasheet
Datasheet
Recommended BRCA2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954189
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954190
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Pig
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN778240
Quantity
96 tests
Datasheet
Datasheet
Recommended BRCA2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122032
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346849
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7504959
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our BRCA2 products
: "Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks." in: Nature communications, Vol. 9, Issue 1, pp. 3882, (2019) (PubMed).: "Expression characteristics of FHIT, p53, BRCA2 and MLH1 in families with a history of oesophageal cancer in a region with a high incidence of oesophageal cancer." in: Oncology letters, Vol. 9, Issue 1, pp. 430-436, (2015) (PubMed).
: "DNA repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 7, pp. 2035-43, (2011) (PubMed).
: "Differential expressions of BRCA1 and BRCA2 in infantile gynecomastia." in: Anticancer research, Vol. 24, Issue 1, pp. 321-4, (2004) (PubMed).
: "BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite." in: Breast cancer research : BCR, Vol. 3, Issue 1, pp. 61-5, (2001) (PubMed).
: "Induction of the BRCA2 promoter by nuclear factor-kappa B." in: The Journal of biological chemistry, Vol. 275, Issue 45, pp. 35548-56, (2000) (PubMed).
: "Low-Dose Ionizing Radiation Affects Mesenchymal Stem Cells via Extracellular Oxidized Cell-Free DNA: A Possible Mediator of Bystander Effect and Adaptive Response." in: Oxidative medicine and cellular longevity, Vol. 2017, pp. 9515809 (PubMed).
Synonyms and alternative names related to BRCA2
BRCA2, DNA repair associated (BRCA2), Breast cancer 2, early onset homolog (Brca2), BRCA2, DNA repair associated (Brca2), breast cancer 2, early onset (brca2), breast cancer 2, early onset (LOC584780), BRCA2, DNA repair associated (brca2), breast cancer 2, early onset (Brca2), 30169, AI256696, AW045498, BcDNA:SD25109, brca2, BRCA2, BRCC2, brcc2, BROVCA2, brovca2, CG13583, CG13584, CG30169, dmbrca2, Dmel\\CG30169, FACD, facd, FAD, fad, FAD1, fad1, FANCB, fancb, FANCD, FANCD1, fancd1, Fancd1, GLM3, PNCA2, RAB163Protein level used designations for BRCA2
- BRCA1/BRCA2-containing complex, subunit 2
- breast and ovarian cancer susceptibility gene, early onset
- breast cancer 2 tumor suppressor
- breast cancer type 2 susceptibility protein
- fanconi anemia group D1 protein
- truncated breast and ovarian cancer susceptibility protein 2
- breast cancer 2, early onset homolog
- CG30169-PA
- Brca2-PA
- breast cancer 2, mutation 1, University of Wisconsin-Madison
- breast cancer susceptibility protein 2
- breast cancer type 2 susceptibility protein homolog
- fanconi anemia group D1 protein homolog
- breast and ovarian cancer susceptibility protein 2
- breast cancer 2, early onset
- breast cancer type 2 susceptibility protein-like
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