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BRCA2 Products

(Breast Cancer 2, Early Onset (BRCA2))
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008].

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Featured BRCA2 Categories

BRCA2 Antibodies

High quality antibodies with extensive validation data.

BRCA2 ELISA Kits

Reliable ELISA kits for a wide range of species.

BRCA2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended BRCA2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p)
Validations
  • (2)
  • (1)
Cat. No. ABIN673434
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB, IHC, IF
Validations
  • (7)
Cat. No. ABIN7234156
Quantity 200 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (3)
Cat. No. ABIN7433543
Quantity 100 μL
Datasheet Datasheet

Recommended BRCA2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6954189
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6954190
Quantity 96 tests
Datasheet Datasheet
Reactivity Pig
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN778240
Quantity 96 tests
Datasheet Datasheet

Recommended BRCA2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122032
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346849
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7504959
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our BRCA2 products

Whelan, Lee, Yin, Ofri, Bermudez-Hernandez, Keegan, Fenyo, Rothenberg: "Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks." in: Nature communications, Vol. 9, Issue 1, pp. 3882, (2019) (PubMed).

Chang, Zhang, Chang, Song, Qin, Chang, Guo, Wei: "Expression characteristics of FHIT, p53, BRCA2 and MLH1 in families with a history of oesophageal cancer in a region with a high incidence of oesophageal cancer." in: Oncology letters, Vol. 9, Issue 1, pp. 430-436, (2015) (PubMed).

Moeller, Yordy, Williams, Giri, Raju, Molkentine, Byers, Heymach, Story, Lee, Sturgis, Weber, Garden, Ang, Schwartz: "DNA repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 7, pp. 2035-43, (2011) (PubMed).

Bernard-Gallon, Dechelotte, Le Corre, Chalabi, Vissac-Sabatier, Bignon: "Differential expressions of BRCA1 and BRCA2 in infantile gynecomastia." in: Anticancer research, Vol. 24, Issue 1, pp. 321-4, (2004) (PubMed).

Bernard-Gallon, Déchelotte, Vissac, Aunoble, Cravello, Malpuech, Bignon: "BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite." in: Breast cancer research : BCR, Vol. 3, Issue 1, pp. 61-5, (2001) (PubMed).

Wu, Jiang, Thangaraju, Wu, Couch: "Induction of the BRCA2 promoter by nuclear factor-kappa B." in: The Journal of biological chemistry, Vol. 275, Issue 45, pp. 35548-56, (2000) (PubMed).

Sergeeva, Ershova, Veiko, Malinovskaya, Kalyanov, Kameneva, Stukalov, Dolgikh, Konkova, Ermakov, Veiko, Izhevskaya, Kutsev, Kostyuk: "Low-Dose Ionizing Radiation Affects Mesenchymal Stem Cells via Extracellular Oxidized Cell-Free DNA: A Possible Mediator of Bystander Effect and Adaptive Response." in: Oxidative medicine and cellular longevity, Vol. 2017, pp. 9515809 (PubMed).

Synonyms and alternative names related to BRCA2

BRCA2, DNA repair associated (BRCA2), Breast cancer 2, early onset homolog (Brca2), BRCA2, DNA repair associated (Brca2), breast cancer 2, early onset (brca2), breast cancer 2, early onset (LOC584780), BRCA2, DNA repair associated (brca2), breast cancer 2, early onset (Brca2), 30169, AI256696, AW045498, BcDNA:SD25109, brca2, BRCA2, BRCC2, brcc2, BROVCA2, brovca2, CG13583, CG13584, CG30169, dmbrca2, Dmel\\CG30169, FACD, facd, FAD, fad, FAD1, fad1, FANCB, fancb, FANCD, FANCD1, fancd1, Fancd1, GLM3, PNCA2, RAB163

Protein level used designations for BRCA2

  • BRCA1/BRCA2-containing complex, subunit 2
  • breast and ovarian cancer susceptibility gene, early onset
  • breast cancer 2 tumor suppressor
  • breast cancer type 2 susceptibility protein
  • fanconi anemia group D1 protein
  • truncated breast and ovarian cancer susceptibility protein 2
  • breast cancer 2, early onset homolog
  • CG30169-PA
  • Brca2-PA
  • breast cancer 2, mutation 1, University of Wisconsin-Madison
  • breast cancer susceptibility protein 2
  • breast cancer type 2 susceptibility protein homolog
  • fanconi anemia group D1 protein homolog
  • breast and ovarian cancer susceptibility protein 2
  • breast cancer 2, early onset
  • breast cancer type 2 susceptibility protein-like
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