BRCA1 Products
(Breast Cancer 1 (BRCA1))
Categories
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
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Featured BRCA1 Categories
BRCA1 Antibodies
High quality antibodies with extensive validation data.
BRCA1 ELISA Kits
Reliable ELISA kits for a wide range of species.
BRCA1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended BRCA1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (2)
- (9)
Cat. No.
ABIN1513831
Quantity
1000 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7433579
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA
Validations
- (1)
- (5)
Cat. No.
ABIN1724848
Quantity
100 μL
Datasheet
Datasheet
Recommended BRCA1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965234
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954188
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380829
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended BRCA1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346847
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346845
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7504943
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our BRCA1 products
: "Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury. ..." in: The Journal of clinical investigation, Vol. 129, Issue 2, pp. 786-801, (2019) (PubMed).: "PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells." in: Journal of experimental & clinical cancer research : CR, Vol. 37, Issue 1, pp. 153, (2018) (PubMed).
: "Therapeutic Impact of Nanoparticle Therapy Targeting Tumor-Associated Macrophages." in: Molecular cancer therapeutics, Vol. 17, Issue 1, pp. 96-106, (2018) (PubMed).
: "Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination." in: Cell death & disease, Vol. 9, Issue 10, pp. 1016, (2018) (PubMed).
: "Di (2-ethylhexyl) phthalate exposure impairs meiotic progression and DNA damage repair in fetal mouse oocytes in vitro." in: Cell death & disease, Vol. 8, Issue 8, pp. e2966, (2017) (PubMed).
: "Artemisinin mimics calorie restriction to trigger mitochondrial biogenesis and compromise telomere shortening in mice." in: PeerJ, Vol. 3, pp. e822, (2015) (PubMed).
: "Characterization of the platelet-derived growth factor receptor-α-positive cell lineage during murine late lung development." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 309, Issue 9, pp. L942-58, (2015) (PubMed).
: "Homozygous mutation of MTPAP causes cellular radiosensitivity and persistent DNA double-strand breaks." in: Cell death & disease, Vol. 5, pp. e1130, (2014) (PubMed).
: "Quantitative measurement of alterations in DNA damage repair (DDR) pathways using single cell network profiling (SCNP)." in: Journal of translational medicine, Vol. 12, pp. 184, (2014) (PubMed).
: "Validation of the BRCA1 antibody MS110 and the utility of BRCA1 as a patient selection biomarker in immunohistochemical analysis of breast and ovarian tumours." in: Virchows Archiv : an international journal of pathology, Vol. 462, Issue 3, pp. 269-79, (2013) (PubMed).
Synonyms and alternative names related to BRCA1
BRCA1, DNA repair associated (BRCA1), breast cancer 1 (brca1), breast cancer 1, early onset (LOC755086), breast cancer 1, early onset (Brca1), BRCA1, DNA repair associated (Brca1), breast cancer 1, early onset (BRCA1), breast cancer 1 L homeolog (brca1.L), brca1, BRCA1, BRCAI, brcai, BRCC1, brcc1, BROVCA1, IRIS, iris, LOC100224649, PNCA4, PPP1R53, PSCP, pscp, RNF53, rnf53Protein level used designations for BRCA1
- BRCA1/BRCA2-containing complex, subunit 1
- RING finger protein 53
- breast and ovarian cancer susceptibility protein 1
- breast and ovarian cancer sususceptibility protein 1
- breast cancer type 1 susceptibility protein
- protein phosphatase 1, regulatory subunit 53
- BRCA1 homologue
- breast cancer type 1 susceptibility protein homolog
- breast cancer 1, early onset
- BRCA1 homolog
- breast and ovarian cancer susceptibility protein
- breast cancer associated 1
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