BPTF Products
(Bromodomain PHD Finger Transcription Factor (BPTF))
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This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008].
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BPTF Antibodies
High quality antibodies with extensive validation data.
Recommended BPTF Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (6)
Cat. No.
ABIN7073234
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro), ICC
Validations
- (3)
Cat. No.
ABIN1386560
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
- (2)
Cat. No.
ABIN968990
Quantity
100 μL
Datasheet
Datasheet
Recommended BPTF Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122052
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
Cat. No.
ABIN2669695
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our BPTF products
: "Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes." in: eLife, Vol. 8, (2019) (PubMed).: "Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z." in: The Journal of biological chemistry, Vol. 285, Issue 7, pp. 4645-51, (2010) (PubMed).
: "BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9804-13, (2009) (PubMed).
: "B-cell linker protein prevents aneuploidy by inhibiting cytokinesis." in: Cancer science, Vol. 99, Issue 12, pp. 2444-54, (2008) (PubMed).
: "Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells." in: PLoS genetics, Vol. 4, Issue 10, pp. e1000241, (2008) (PubMed).
: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, (2008) (PubMed).
Synonyms and alternative names related to BPTF
bromodomain PHD finger transcription factor (BPTF), bromodomain PHD finger transcription factor (Bptf), nucleosome-remodeling factor subunit NURF301 (LOC5576547), fetal alzheimer antigen, falz (CpipJ_CPIJ011285), bromodomain PHD finger transcription factor (bptf), 9430093H17Rik, BPTF, FAC1, FALZ, Falz, NURF301Protein level used designations for BPTF
- bromodomain and PHD domain transcription factor
- bromodomain and PHD finger-containing transcription factor
- fetal Alz-50 clone 1 protein
- fetal Alz-50 reactive clone 1
- fetal Alzheimer antigen
- nucleosome remodeling factor, large subunit
- nucleosome-remodeling factor subunit BPTF
- fetal alzheimer antigen, falz
- bromodomain PHD finger transcription factor
- nucleosome-remodeling factor subunit BPTF-like
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