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BIM Products

(BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jul 2008].

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Featured BIM Categories

BIM Antibodies

High quality antibodies with extensive validation data.

BIM ELISA Kits

Reliable ELISA kits for a wide range of species.

BIM Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended BIM Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, ICC, IP
Validations
  • (8)
Cat. No. ABIN7430234
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), FACS
Validations
  • (4)
Cat. No. ABIN652493
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA, IF
Validations
  • (3)
Cat. No. ABIN7145302
Quantity 100 μg
Datasheet Datasheet

Recommended BIM ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965138
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6954063
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380955
Quantity 96 tests
Datasheet Datasheet

Recommended BIM Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346560
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346562
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346558
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our BIM products

Peperzak, Slinger, Ter Burg, Eldering: "Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling." in: Cell death and differentiation, Vol. 24, Issue 1, pp. 111-119, (2018) (PubMed).

Jiao, Li, Zhang, Liu, Chi: "Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells." in: Biochemical and biophysical research communications, Vol. 480, Issue 3, pp. 387-393, (2017) (PubMed).

Luan, Jin, Jiang, Tay, Lai, Liu, Liu, Guo, Li, Yan, Tseng, Zhang: "RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy." in: Autophagy, Vol. 11, Issue 7, pp. 975-94, (2015) (PubMed).

Wang, Lv, Cheng, Du, Chen, Li, Zhang: "Apoptosis induced by Ginkgo biloba (EGb761) in melanoma cells is Mcl-1-dependent." in: PLoS ONE, Vol. 10, Issue 4, pp. e0124812, (2015) (PubMed).

Renault, Elkholi, Bharti, Chipuk: "B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins." in: The Journal of biological chemistry, Vol. 289, Issue 38, pp. 26481-91, (2014) (PubMed).

Lee, Maeng, Kang, Choi, Oh, Ju, Yune: "Valproic acid protects motor neuron death by inhibiting oxidative stress and endoplasmic reticulum stress-mediated cytochrome C release after spinal cord injury." in: Journal of neurotrauma, Vol. 31, Issue 6, pp. 582-94, (2014) (PubMed).

Gogada, Yadav, Liu, Tang, Zhang, Schneider, Seshadri, Sun, Aldaz, Tang, Chandra: "Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer." in: The Journal of biological chemistry, Vol. 288, Issue 1, pp. 368-81, (2013) (PubMed).

Wroblewski, Jiang, Croft, Farrelly, Zhang, Hersey: "OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis." in: PLoS ONE, Vol. 8, Issue 12, pp. e84073, (2013) (PubMed).

Tay, Jin, Tseng, Jiang, Ye, Thorne, Liu, Guo, Verrills, Hersey, Zhang: "Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress." in: Cell death & disease, Vol. 3, pp. e337, (2012) (PubMed).

Cash, Gruber, Hartman, Henske, Simon: "Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription." in: Oncogene, Vol. 30, Issue 22, pp. 2534-46, (2011) (PubMed).

Synonyms and alternative names related to BIM

BCL2-like 11 (bcl2l11), BCL2 like 11 (BCL2L11), BCL2-like 11 (apoptosis facilitator) (Bcl2l11), BCL2 like 11 (Bcl2l11), 1500006F24Rik, BAM, bim, BIM, Bim, BIMEL, BimL, BOD, Bod

Protein level used designations for BIM

  • BCL2-like 11
  • Bcl-2 interacting mediator of cell death
  • bcl-2 interacting mediator of cell death
  • bcl-2 interacting protein Bim
  • bcl-2-like protein 11
  • bcl-2-related ovarian death agonist
  • Bcl2 interacting mediator of cell death
  • bcl2-L-11
  • bcl2-interacting mediator of cell death
  • Bcl-2 related apoptotic gene product BimL
  • bcl-2-related ovarian death protein
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