BIK Products
(BCL2-Interacting Killer (Apoptosis-Inducing) (BIK))
Categories
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011].
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Featured BIK Categories
BIK Antibodies
High quality antibodies with extensive validation data.
BIK ELISA Kits
Reliable ELISA kits for a wide range of species.
BIK Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended BIK Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, ELISA, IF, ICC
Validations
- (5)
Cat. No.
ABIN6260261
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p), FACS
Validations
- (6)
Cat. No.
ABIN4950330
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN388114
Quantity
400 μL
Datasheet
Datasheet
Recommended BIK ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380102
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended BIK Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346675
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346677
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3099669
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our BIK products
: "β-arrestin-2 enhances intestinal epithelial apoptosis in necrotizing enterocolitis." in: Aging, Vol. 11, Issue 19, pp. 8294-8312, (2019) (PubMed).: "Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts." in: Arthritis research & therapy, Vol. 20, Issue 1, pp. 55, (2018) (PubMed).
: "Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik." in: Molecular and cellular biology, Vol. 34, Issue 18, pp. 3435-49, (2014) (PubMed).
: "Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity." in: Blood, Vol. 109, Issue 10, pp. 4360-7, (2007) (PubMed).
: "TNF pretreatment interferes with mitochondrial apoptosis in the mouse liver by A20-mediated down-regulation of Bax." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 10, pp. 7042-9, (2007) (PubMed).
: "The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through ..." in: The Journal of biological chemistry, Vol. 281, Issue 35, pp. 25850-66, (2006) (PubMed).
: "Transcriptional activation of the proapoptotic bik gene by E2F proteins in cancer cells." in: FEBS letters, Vol. 580, Issue 25, pp. 5905-9, (2006) (PubMed).
: "Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis." in: The EMBO journal, Vol. 24, Issue 8, pp. 1546-56, (2005) (PubMed).
: "BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death." in: The Journal of biological chemistry, Vol. 280, Issue 25, pp. 23829-36, (2005) (PubMed).
: "BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria." in: The Journal of biological chemistry, Vol. 277, Issue 20, pp. 18053-60, (2002) (PubMed).
Synonyms and alternative names related to BIK
BCL2 interacting killer (BIK), BCL2-interacting killer (Bik), BCL2-interacting killer (apoptosis-inducing) (bik), BIK, Biklk, BIP1, Blk, BP4, Nbk, NBK, si:dkey-31f5.6Protein level used designations for BIK
- BCL2-interacting killer (apoptosis-inducing)
- BCL2-interacting killer
- apoptosis inducer NBK
- bcl-2-interacting killer
- bik-like killer protein
- apoptosis-inducing NBK
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