BCCIP Products
(BRCA2 and CDKN1A Interacting Protein (BCCIP))
Categories
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Featured BCCIP Categories
BCCIP Antibodies
High quality antibodies with extensive validation data.
BCCIP ELISA Kits
Reliable ELISA kits for a wide range of species.
BCCIP Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended BCCIP Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), ICC
Validations
- (4)
Cat. No.
ABIN2856892
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN6137485
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN527937
Quantity
50 μg
Datasheet
Datasheet
Recommended BCCIP ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730078
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1124123
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Cow
Analytical Method
Validations
Cat. No.
ABIN1124121
Quantity
96 tests
Datasheet
Datasheet
Recommended BCCIP Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122031
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346518
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346520
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our BCCIP products
: "The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair." in: Molecular and cellular biology, Vol. 25, Issue 5, pp. 1949-57, (2005) (PubMed).: "Inhibition of G1 to S cell cycle progression by BCCIP beta." in: Cell cycle (Georgetown, Tex.), Vol. 3, Issue 3, pp. 343-8, (2004) (PubMed).
: "Unique de novo mutation of BRCA2 in a woman with early onset breast cancer." in: Journal of medical genetics, Vol. 39, Issue 2, pp. 126-8, (2002) (PubMed).
: "Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2." in: Oncogene, Vol. 20, Issue 3, pp. 336-45, (2001) (PubMed).
: "TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase." in: The Journal of biological chemistry, Vol. 275, Issue 40, pp. 31145-54, (2000) (PubMed).
Synonyms and alternative names related to BCCIP
BRCA2 and CDKN1A interacting protein (BCCIP), BRCA2 and CDKN1A interacting protein (bccip), BRCA2 and CDKN1A interacting protein L homeolog (bccip.L), BRCA2 and CDKN1A interacting protein (Bccip), 1110013J05Rik, BCCIP, DKFZp459K2416, MGC82792, MGC89311, mp:zf637-1-000774, tok-1, TOK-1, TOK1, zgc:110272Protein level used designations for BCCIP
- BRCA2 and CDKN1A interacting protein
- protein BCCIP homolog
- BRCA2 and CDKN1A-interacting protein
- bccip-like
- BCCIPalpha
- BCCIPbeta
- BRCA2 and Cip1/p21 interacting protein
- TOK-1alpha
- TOK-1beta
- cdk inhibitor p21 binding protein
- p21- and CDK-associated protein 1
- protein TOK-1
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