BCAT1 Products
(Branched Chain Amino-Acid Transaminase 1, Cytosolic (BCAT1))
Categories
This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010].
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Featured BCAT1 Categories
BCAT1 Antibodies
High quality antibodies with extensive validation data.
BCAT1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended BCAT1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7445063
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7445177
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7445060
Quantity
100 μL
Datasheet
Datasheet
Recommended BCAT1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6227409
Quantity
96 tests
Datasheet
Datasheet
Recommended BCAT1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122027
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346515
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7419871
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our BCAT1 products
: "Defect of branched-chain amino acid metabolism promotes the development of Alzheimer's disease by targeting the mTOR signaling." in: Bioscience reports, Vol. 38, Issue 4, (2018) (PubMed).: "BCAT1 is a New MR Imaging-related Biomarker for Prognosis Prediction in IDH1-wildtype Glioblastoma Patients." in: Scientific reports, Vol. 7, Issue 1, pp. 17740, (2017) (PubMed).
: "Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia." in: Nature, Vol. 545, Issue 7655, pp. 500-504, (2017) (PubMed).
: "Smed-betacatenin-1 is required for anteroposterior blastema polarity in planarian regeneration." in: Science (New York, N.Y.), Vol. 319, Issue 5861, pp. 327-30, (2008) (PubMed).
: "Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines." in: The Journal of biological chemistry, Vol. 274, Issue 31, pp. 21528-32, (1999) (PubMed).
: "Involvement of Myc targets in c-myc and N-myc induced human tumors." in: Oncogene, Vol. 17, Issue 2, pp. 165-71, (1998) (PubMed).
: "High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity." in: The Journal of biological chemistry, Vol. 272, Issue 13, pp. 8474-81, (1997) (PubMed).
: "ECA39 is regulated by c-Myc in human and by a Jun/Fos homolog, Gcn4, in yeast." in: Oncogene, Vol. 13, Issue 9, pp. 1859-66, (1997) (PubMed).
: "Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B." in: Nature, Vol. 378, Issue 6559, pp. 785-9, (1996) (PubMed).
: "Two yeast homologs of ECA39, a target for c-Myc regulation, code for cytosolic and mitochondrial branched-chain amino acid aminotransferases." in: The Journal of biological chemistry, Vol. 271, Issue 34, pp. 20242-5, (1996) (PubMed).
Synonyms and alternative names related to BCAT1
branched chain amino-acid transaminase 1, cytosolic (bcat1), branched chain amino acid transaminase 1 (BCAT1), branched chain amino-acid transaminase 1, cytosolic L homeolog (bcat1.L), branched chain aminotransferase 1, cytosolic (bcat1), branched chain amino acid transaminase 1 (bcat1), branched chain amino acid transaminase 1 (Bcat1), branched chain aminotransferase 1, cytosolic (Bcat1), Bcatc, BCATC, BCATc, BCT1, ECA39, Eca39, fj66g02, MECA39, PNAS121, PP18, wu:fj66g02, zgc:73157Protein level used designations for BCAT1
- branched-chain-amino-acid aminotransferase, cytosolic
- branched chain aminotransferase 1, cytosolic
- branched chain amino-acid transaminase 1, cytosolic
- branched-chain-amino-acid aminotransferase, cytosolic-like
- BCAT(c)
- placental protein 18
- cytosolic branched-chain amino acid aminotransferase
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