BCAR3 Products
(Breast Cancer Anti-Estrogen Resistance 3 (BCAR3))
Categories
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
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Featured BCAR3 Categories
BCAR3 Antibodies
High quality antibodies with extensive validation data.
BCAR3 ELISA Kits
Reliable ELISA kits for a wide range of species.
BCAR3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended BCAR3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (4)
Cat. No.
ABIN6260215
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6257959
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN563616
Quantity
100 μg
Datasheet
Datasheet
Recommended BCAR3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965237
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954192
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN5648159
Quantity
96 tests
Datasheet
Datasheet
Recommended BCAR3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346502
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7414060
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2715176
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our BCAR3 products
: "Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions." in: Molecular and cellular biology, Vol. 32, Issue 18, pp. 3776-89, (2012) (PubMed).: "Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling." in: Cancer research, Vol. 67, Issue 13, pp. 6174-82, (2007) (PubMed).
: "Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells." in: The EMBO journal, Vol. 17, Issue 10, pp. 2799-808, (1998) (PubMed).
Synonyms and alternative names related to BCAR3
breast cancer anti-estrogen resistance 3 (BCAR3), breast cancer anti-estrogen resistance 3 (Bcar3), breast cancer anti-estrogen resistance 3 (bcar3), breast cancer anti-estrogen resistance 3 L homeolog (bcar3.L), AI131758, AND-34, BCAR3, NSP2, SH2D3BProtein level used designations for BCAR3
- SH2 domain-containing protein 3B
- breast cancer anti-estrogen resistance protein 3
- breast cancer antiestrogen resistance 3 protein
- dJ1033H22.2 (breast cancer anti-estrogen resistance 3)
- novel SH2-containing protein 2
- p130Cas-binding protein AND-34
- breast cancer anti-estrogen resistance 3
- breast cancer antiestrogen resistance 3
- breast cancer anti-estrogen resistance protein 3-like
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