B-Cell Linker Products
(B-Cell Linker (BLNK))
Categories
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012].
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Featured B-Cell Linker Categories
B-Cell Linker Antibodies
High quality antibodies with extensive validation data.
B-Cell Linker ELISA Kits
Reliable ELISA kits for a wide range of species.
B-Cell Linker Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended B-Cell Linker Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (2)
- (6)
Cat. No.
ABIN968984
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ICC, IP
Validations
- (6)
Cat. No.
ABIN7441781
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS, IF
Validations
- (4)
Cat. No.
ABIN184602
Quantity
100 μg
Datasheet
Datasheet
Recommended B-Cell Linker ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380804
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380291
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Pig
Analytical Method
Quantitative
Validations
Cat. No.
ABIN778228
Quantity
96 tests
Datasheet
Datasheet
Recommended B-Cell Linker Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346719
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346721
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121966
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our B-Cell Linker products
: "Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects." in: PLoS ONE, Vol. 8, Issue 10, pp. e76115, (2013) (PubMed).: "Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling." in: Cellular oncology (Dordrecht), Vol. 34, Issue 2, pp. 141-53, (2011) (PubMed).
: "BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9804-13, (2009) (PubMed).
: "Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions." in: Blood, Vol. 113, Issue 23, pp. 5878-86, (2009) (PubMed).
: "B-cell linker protein prevents aneuploidy by inhibiting cytokinesis." in: Cancer science, Vol. 99, Issue 12, pp. 2444-54, (2008) (PubMed).
: "SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond." in: Nature reviews. Immunology, Vol. 6, Issue 1, pp. 67-78, (2006) (PubMed).
: "The SLP-76 family of adapter proteins." in: Seminars in immunology, Vol. 16, Issue 6, pp. 379-93, (2004) (PubMed).
: "Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells." in: Immunology, Vol. 112, Issue 4, pp. 575-82, (2004) (PubMed).
: "Adaptor proteins in lymphocyte activation." in: Current opinion in immunology, Vol. 15, Issue 3, pp. 269-76, (2003) (PubMed).
: "Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells." in: The Journal of experimental medicine, Vol. 198, Issue 1, pp. 91-8, (2003) (PubMed).
Synonyms and alternative names related to B-Cell Linker
B-cell linker (BLNK), B-cell linker (blnk), B cell linker (Blnk), B-cell linker (Blnk), AGM4, BASH, Bca, bca, BLNK, blnk, BLNK-S, Ly-57, Ly57, LY57, Lyw-57, MGC147045, SLP-65, SLP65Protein level used designations for B-Cell Linker
- B-cell linker
- B-cell linker protein
- b-cell linker protein-like
- B-cell adapter containing a SH2 domain protein
- B-cell adapter containing a Src homology 2 domain protein
- cytoplasmic adapter protein
- lymphocyte antigen 57
- src homology 2 domain-containing leukocyte protein of 65 kDa
- B cell adaptor containing SH2 domain
- B cell linker protein
- B-cell activation
- Src homology 2 domain-containing leukocyte protein of 65 kDa
- Src homology [SH2] domain-containing leukocyte protein of 65 kD
- B cell linker protein BLNK
- B-cell adapter SH2 domain-containing protein
- SLP-65
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