Band 3/AE1 Products
(Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))
Categories
The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. [provided by RefSeq, Jul 2008].
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Featured Band 3/AE1 Categories
Band 3/AE1 Antibodies
High quality antibodies with extensive validation data.
Band 3/AE1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Band 3/AE1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC (p), ICC, IHC (fro)
Validations
- (8)
Cat. No.
ABIN7441895
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN7270459
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p), IHC (fro)
Validations
- (5)
Cat. No.
ABIN3043930
Quantity
100 μg
Datasheet
Datasheet
Recommended Band 3/AE1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125166
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320468
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
Cat. No.
ABIN7199706
Quantity
2 μg
Datasheet
Datasheet
Latest Publications for our Band 3/AE1 products
: "Eryptotic phenotype in chronic myeloid leukemia: contribution of neutrophilic cathepsin g." in: Anemia, Vol. 2012, pp. 659303, (2012) (PubMed).Synonyms and alternative names related to Band 3/AE1
solute carrier family 4 member 1 (Diego blood group) (SLC4A1), solute carrier family 4 (anion exchanger), member 1 (Slc4a1), solute carrier family 4 (anion exchanger), member 1a (Diego blood group) (slc4a1a), Band 3 (LOC100136769), erythrocyte membrane protein band 4.1 like 3 (EPB41L3), solute carrier family 4 member 1 (Diego blood group) L homeolog (slc4a1.L), solute carrier family 4 member 1 (SLC4A1), solute carrier family 4 member 1 (Diego blood group) (slc4a1), solute carrier family 4 member 1 (Slc4a1), AE1, Ae1, ae1, band3, BB3, BND3, bnd3, CD233, cd233, DI, EAT, EMPB3, Empb3, empb3, EPB3, epb3, FR, l11Jus51, LOC100136769, MGC80391, MGC152771, RTA1A, rta1a, si:dz180g5.1, slc4a1, SLC4A1, SW, WD, WD1, wd1, WR, zgc:111889, zgc:152771Protein level used designations for Band 3/AE1
- Diego blood group
- Froese blood group
- Swann blood group
- Waldner blood group
- Wright blood group
- anion exchange protein 1
- anion exchanger 1
- anion exchanger-1
- band 3 anion transport protein
- erythrocyte membrane protein band 3
- erythroid anion exchange protein
- solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
- solute carrier family 4, anion exchanger, number 1
- AE 1
- MEB3
- solute carrier family 4 member 1
- solute carrier family 4, anion exchanger, member 1
- ret
- retsina
- AE1/band 3
- erythroid anion exchanger 1
- Band 3
- band 4.1-like protein 3-like
- solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3)
- band 3 anion transport protein-like
- erythroid-specific band 3 protein
- erythrocyte anion transport protein
- Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3)
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