BAG4 Products
(BCL2-Associated Athanogene 4 (BAG4))
Categories
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011].
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Featured BAG4 Categories
BAG4 Antibodies
High quality antibodies with extensive validation data.
BAG4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended BAG4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7145218
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
Cat. No.
ABIN523013
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN523015
Quantity
100 μg
Datasheet
Datasheet
Recommended BAG4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6212945
Quantity
96 tests
Datasheet
Datasheet
Recommended BAG4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346372
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346370
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7420267
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our BAG4 products
: "GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress-Induced Apoptosis." in: Journal of cellular biochemistry, Vol. 117, Issue 8, pp. 1813-21, (2016) (PubMed).: "Expression of Bcl-2 and the antiapoptotic BAG family proteins in ovarian cancer." in: Applied immunohistochemistry & molecular morphology : AIMM, Vol. 21, Issue 6, pp. 518-24, (2013) (PubMed).
: "Hypermutation induced by APOBEC-1 overexpression can be eliminated." in: RNA (New York, N.Y.), Vol. 16, Issue 5, pp. 1040-52, (2010) (PubMed).
: "Heat shock protein 70 (Hsp70): membrane location, export and immunological relevance." in: Methods (San Diego, Calif.), Vol. 43, Issue 3, pp. 229-37, (2007) (PubMed).
: "BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 22 Pt 1, pp. 6585-92, (2007) (PubMed).
: "Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells." in: Cancer research, Vol. 65, Issue 12, pp. 5238-47, (2005) (PubMed).
: "Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells." in: Cell death and differentiation, Vol. 12, Issue 1, pp. 38-51, (2004) (PubMed).
: "Role of SODD in regulation of tumor necrosis factor responses." in: Molecular and cellular biology, Vol. 23, Issue 11, pp. 4026-33, (2003) (PubMed).
: "Apparently normal tumor necrosis factor receptor 1 signaling in the absence of the silencer of death domains." in: Molecular and cellular biology, Vol. 23, Issue 18, pp. 6609-17, (2003) (PubMed).
: "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 24, pp. 12829-32, (1998) (PubMed).
Synonyms and alternative names related to BAG4
BCL2 associated athanogene 4 (BAG4), BCL2-associated athanogene 4 (Bag4), BCL2-associated athanogene 4 (bag4), BCL-2-associated athanogene 4 (BAG4), BCL2 associated athanogene 4 (Bag4), 2410112I15Rik, ATBAG4, BAG-4, BAG4, BCL-2-associated athanogene 4, fd20a04, si:dkey-220o5.3, SODD, wu:fd20a04Protein level used designations for BAG4
- BAG family molecular chaperone regulator 4
- BAG-family molecular chaperone regulator-4
- bcl-2-associated athanogene 4
- silencer of death domains
- BCL2-associated athanogene 4
- BAG-4
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