BACE2 Products
(beta-Site APP-Cleaving Enzyme 2 (BACE2))
Categories
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Featured BACE2 Categories
BACE2 Antibodies
High quality antibodies with extensive validation data.
BACE2 ELISA Kits
Reliable ELISA kits for a wide range of species.
BACE2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended BACE2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7434101
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (8)
Cat. No.
ABIN7438730
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (5)
Cat. No.
ABIN7265880
Quantity
100 μL
Datasheet
Datasheet
Recommended BACE2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
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Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
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Cat. No.
ABIN6965162
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965163
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN770620
Quantity
96 tests
Datasheet
Datasheet
Recommended BACE2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121999
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346347
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7194384
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our BACE2 products
: "BACE-2 is overexpressed in Down's syndrome." in: Experimental neurology, Vol. 182, Issue 2, pp. 335-45, (2003) (PubMed).: "Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells." in: The Journal of biological chemistry, Vol. 278, Issue 34, pp. 31512-20, (2003) (PubMed).
: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).
: "The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region." in: FEBS letters, Vol. 468, Issue 1, pp. 59-64, (2000) (PubMed).
: "Expression analysis of BACE2 in brain and peripheral tissues." in: The Journal of biological chemistry, Vol. 275, Issue 27, pp. 20647-51, (2000) (PubMed).
: "BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 17, pp. 9712-7, (2000) (PubMed).
: "Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 4, pp. 1457-62, (1999) (PubMed).
: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, (1999) (PubMed).
: "A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma." in: Nature medicine, Vol. 3, Issue 8, pp. 917-21, (1997) (PubMed).
Synonyms and alternative names related to BACE2
beta-site APP-cleaving enzyme 2 (BACE2), beta-site APP-cleaving enzyme 2 (Bace2), 1110059C24Rik, AEPLC, AI850424, ALP56, ARP1, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAPProtein level used designations for BACE2
- 56 kDa aspartic-like protease
- Down syndrome region aspartic protease
- aspartyl protease 1
- beta-secretase 2
- beta-site amyloid beta A4 precursor protein-cleaving enzyme 2
- memapsin-1
- membrane-associated aspartic protease 1
- theta-secretase
- transmembrane aspartic proteinase Asp1
- ASP1
- asp 1
- beta-site APP cleaving enzyme 2
- beta-site amyloid precursor protein cleaving enzyme 2
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