BACE1 Products
(Beta-secretase 1 (BACE1))
Categories
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011].
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Featured BACE1 Categories
BACE1 Antibodies
High quality antibodies with extensive validation data.
BACE1 ELISA Kits
Reliable ELISA kits for a wide range of species.
BACE1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended BACE1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, ICC, FACS
Validations
- (6)
Cat. No.
ABIN2682977
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), PLA
Validations
- (6)
Cat. No.
ABIN2566113
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC, IF
Validations
- (6)
Cat. No.
ABIN2782766
Quantity
100 μL
Datasheet
Datasheet
Recommended BACE1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6954088
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6963107
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965161
Quantity
96 tests
Datasheet
Datasheet
Recommended BACE1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7273905
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7273904
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7273906
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our BACE1 products
: "Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration." in: Nature communications, Vol. 13, Issue 1, pp. 5308, (2022) (PubMed).: "Extracellular vesicles: where the amyloid precursor protein carboxyl-terminal fragments accumulate and amyloid-β oligomerizes." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 34, Issue 9, pp. 12922-12931, (2021) (PubMed).
: "A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients." in: Neurobiology of aging, Vol. 84, pp. 26-32, (2020) (PubMed).
: "Inhibition of BACE1, the β-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus." in: Neural regeneration research, Vol. 15, Issue 8, pp. 1546-1553, (2020) (PubMed).
: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." in: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, (2018) (PubMed).
: "Comparative study of the effects of phosphatidylcholine rich in DHA and EPA on Alzheimer's disease and the possible mechanisms in CHO-APP/PS1 cells and SAMP8 mice." in: Food & function, Vol. 9, Issue 1, pp. 643-654, (2018) (PubMed).
: "Thymoquinone-rich fraction nanoemulsion (TQRFNE) decreases Aβ40 and Aβ42 levels by modulating APP processing, up-regulating IDE and LRP1, and down-regulating BACE1 and RAGE in response to high ..." in: Biomedicine & pharmacotherapy, Vol. 95, pp. 780-788, (2018) (PubMed).
: "An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity." in: PLoS ONE, Vol. 11, Issue 11, pp. e0166415, (2017) (PubMed).
: "Dopamine D2 receptor and β-arrestin 2 mediate Amyloid-β elevation induced by anti-parkinson's disease drugs, levodopa and piribedil, in neuronal cells." in: PLoS ONE, Vol. 12, Issue 3, pp. e0173240, (2017) (PubMed).
: "Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus." in: Neurochemical research, Vol. 41, Issue 5, pp. 1192-9, (2016) (PubMed).
Synonyms and alternative names related to BACE1
beta-secretase 1 (BACE1), beta-site APP cleaving enzyme 1 (Bace1), beta-secretase 1 (Bace1), beta-site APP-cleaving enzyme 1 (bace1), ASP2, BACE, Bace, BACE1, C76936, HSPC104, MGC145931, zgc:77409Protein level used designations for BACE1
- APP beta-secretase
- asp 2
- aspartyl protease 2
- beta-secretase 1
- beta-secretase 1 precursor variant 1
- beta-site APP cleaving enzyme 1
- beta-site amyloid beta A4 precursor protein-cleaving enzyme
- memapsin-2
- membrane-associated aspartic protease 2
- transmembrane aspartic proteinase Asp2
- ASP2
- beta-site amyloid precursor protein cleaving enzyme 1
- beta-site APP cleaving enzyme
- beta secretase 1
- beta-secretase 1 isoform A preproprotein
- beta-secretase 1 isoform B preproprotein
- beta-secretase 1 isoform C preproprotein
- beta-site APP-cleaving enzyme 1
- beta-secretase 1-like
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