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ATXN7L2 Products

(Ataxin 7-Like 2 (ATXN7L2))

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The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].

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Featured ATXN7L2 Categories

ATXN7L2 Antibodies

High quality antibodies with extensive validation data.

Recommended ATXN7L2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, FACS
Validations
  • (2)
Cat. No. ABIN655240
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN6258382
Quantity 100 μL
Datasheet Datasheet
Reactivity Bat, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN6743251
Quantity 100 μL
Datasheet Datasheet

Recommended ATXN7L2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3089587
Quantity 1 mg
Datasheet Datasheet

Synonyms and alternative names related to ATXN7L2

ataxin 7-like 2 (Atxn7l2), ataxin 7 like 2 (ATXN7L2), ataxin 7-like 2b (atxn7l2b), ataxin 7-like 2a (atxn7l2a), ataxin 7 like 2 (Atxn7l2), 2610528J18Rik, atxn7l2, RGD1307047, wu:fi32b11, wu:fi36e12, zgc:92454, zgc:136546

Protein level used designations for ATXN7L2

  • ataxin-7-like protein 2
  • mFLJ00381 protein
  • ataxin 7-like 1
  • ataxin 7-like 2
  • fi32b11
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