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ATP6V1A Products

(ATPase, H+ Transporting, Lysosomal 70kDa, V1 Subunit A (ATP6V1A))
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008].

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Featured ATP6V1A Categories

ATP6V1A Antibodies

High quality antibodies with extensive validation data.

ATP6V1A ELISA Kits

Reliable ELISA kits for a wide range of species.

ATP6V1A Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ATP6V1A Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IF
Validations
  • (6)
Cat. No. ABIN513626
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC
Validations
  • (3)
Cat. No. ABIN6260133
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (1)
  • (2)
Cat. No. ABIN653735
Quantity 400 μL
Datasheet Datasheet

Recommended ATP6V1A ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5594231
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5594230
Quantity 96 tests
Datasheet Datasheet
Reactivity Cow
Analytical Method
Validations
Cat. No. ABIN1166508
Quantity 96 tests
Datasheet Datasheet

Recommended ATP6V1A Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346111
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346113
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3075317
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our ATP6V1A products

Farsi, Gowrisankaran, Krunic, Rammner, Woehler, Lafer, Mim, Jahn, Milosevic: "Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity." in: eLife, Vol. 7, (2018) (PubMed).

Gokey, Dasgupta, Amack: "The V-ATPase accessory protein Atp6ap1b mediates dorsal forerunner cell proliferation and left-right asymmetry in zebrafish." in: Developmental biology, Vol. 407, Issue 1, pp. 115-30, (2016) (PubMed).

Liberman, Bond, Shainheit, Stadecker, Forgac: "Regulated assembly of vacuolar ATPase is increased during cluster disruption-induced maturation of dendritic cells through a phosphatidylinositol 3-kinase/mTOR-dependent pathway." in: The Journal of biological chemistry, Vol. 289, Issue 3, pp. 1355-63, (2014) (PubMed).

Grubman, Lidgerwood, Duncan, Bica, Tan, Parker, Caragounis, Meyerowitz, Volitakis, Moujalled, Liddell, Hickey, Horne, Longmuir, Koistinaho, Donnelly, Crouch, Tammen, White, Kanninen: "Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder." in: Acta neuropathologica communications, Vol. 2, pp. 25, (2014) (PubMed).

Monteiro, Aires, Becker, Jacinto, Certal, Rodríguez-León: "V-ATPase proton pumping activity is required for adult zebrafish appendage regeneration." in: PLoS ONE, Vol. 9, Issue 3, pp. e92594, (2014) (PubMed).

Nabatov, Hatzis, Rouschop, van Diest, Vooijs: "Hypoxia inducible NOD2 interacts with 3-O-sulfogalactoceramide and regulates vesicular homeostasis." in: Biochimica et biophysica acta, Vol. 1830, Issue 11, pp. 5277-86, (2013) (PubMed).

Matsuda, Okada, Kodama, Honda, Iida: "A cytotoxic type III secretion effector of Vibrio parahaemolyticus targets vacuolar H+-ATPase subunit c and ruptures host cell lysosomes." in: PLoS pathogens, Vol. 8, Issue 7, pp. e1002803, (2012) (PubMed).

Li, Chen, Klemmer, Koopmans, Karupothula, Smit: "Identifying true protein complex constituents in interaction proteomics: the example of the DMXL2 protein complex." in: Proteomics, Vol. 12, Issue 15-16, pp. 2428-32, (2012) (PubMed).

Huang, Chen, Shen, Shen, Guo, Gao, Zou: "Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cells." in: Cancer letters, Vol. 315, Issue 2, pp. 198-205, (2011) (PubMed).

Nylandsted, Becker, Bunkenborg, Andersen, Dengjel, Jäättelä: "ErbB2-associated changes in the lysosomal proteome." in: Proteomics, Vol. 11, Issue 14, pp. 2830-8, (2011) (PubMed).

Synonyms and alternative names related to ATP6V1A

ATPase H+ transporting V1 subunit A (ATP6V1A), ATPase, H+ transporting, lysosomal V1 subunit A (Atp6v1a), ATPase, H+ transporting, lysosomal, V1 subunit Aa (atp6v1aa), ATPase H+ transporting V1 subunit A (Atp6v1a), v-type proton ATPase catalytic subunit A (ANI_1_1468024), v-type proton ATPase catalytic subunit A (AOR_1_602134), vacuolar ATP synthase subunit A (VHA-A), ATPase H+ transporting V1 subunit A L homeolog (atp6v1a.L), vacuolar proton pump 3 (vpp3), Vacuolar H[+] ATPase 68kD subunit 1 (Vha68-1), AI647066, An02g10440, AO090102000349, ATP6A1, Atp6a1, atp6a1, Atp6a2, ATP6V1A, ATP6V1A1, Atp6v1a1, atp6v1a1, atp6v1al, CG12403, Dmel\CG12403, HO68, ho68, V-ATPase, v1a, VA68, va68, vacuolar ATP synthase subunit A, Vha, Vha-68-1, vha67-2, Vha68, vha68-1, Vma1, vma1, VPP2, vpp2, zgc:63516

Protein level used designations for ATP6V1A

  • ATPase, H+ transporting, lysosomal, subunit A1
  • H(+)-transporting two-sector ATPase, subunit A
  • H+-transporting ATPase chain A, vacuolar (VA68 type)
  • V-ATPase 69 kDa subunit 1
  • V-ATPase A subunit 1
  • V-ATPase subunit A
  • V-type proton ATPase catalytic subunit A
  • vacuolar ATP synthase catalytic subunit A, ubiquitous isoform
  • vacuolar ATPase isoform VA68
  • vacuolar proton pump alpha subunit 1
  • vacuolar proton pump subunit alpha
  • ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha polypeptide, 70kD
  • ATPase, H+ transporting, lysosomal V1 subunit A
  • H(+)-ATPase subunit A
  • V-ATPase 69 kDa subunit
  • vacuolar H+-ATPase A subunit
  • 70-kDa subunit
  • ATPase, H+ transporting, V1 subunit A
  • ATPase, H+ transporting, V1 subunit A1
  • ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha 70 kDa
  • ATPase, H+ transporting, lysosomal 70kD, V1 subunit A
  • lysosomal 70kDa
  • ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A, like
  • ATPase, H+ transporting, lysosomal V1 subunit A, like
  • A2 isoform of vacuolar H+-ATPase subunit A
  • H+ ATPase
  • Vacuolar ATP synthase catalytic subunit A
  • IDP1607
  • IDP1607a
  • IDP1607c
  • IDP1662
  • IDP2575
  • IDP2575a
  • IDP2575c
  • PCO134411
  • PCO134411(361)
  • PCO134411_ov
  • PZA00936
  • V-ATPase
  • V-type H+-ATPase
  • nPZA00936-1
  • vacuolar ATPase 69 kDa subunit
  • vpp*-U36436
  • CG12403-PA
  • CG12403-PB
  • Vha68-1-PA
  • Vha68-1-PB
  • vacuolar H[+] ATPase subunit 68-1
  • ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
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