ATP2B4 Products
(ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4))
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The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
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Featured ATP2B4 Categories
ATP2B4 Antibodies
High quality antibodies with extensive validation data.
ATP2B4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ATP2B4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IF, IHC
Validations
- (3)
Cat. No.
ABIN7163520
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN947597
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN947595
Quantity
100 μg
Datasheet
Datasheet
Recommended ATP2B4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346043
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7424053
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3113223
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our ATP2B4 products
: "Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility." in: Cell, Vol. 177, Issue 6, pp. 1480-1494.e19, (2019) (PubMed).: "Single nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression." in: Human molecular genetics, (2019) (PubMed).
: "Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing." in: Nucleic acids research, (2018) (PubMed).
: "Pepino polyphenolic extract improved oxidative, inflammatory and glycative stress in the sciatic nerves of diabetic mice." in: Food & function, Vol. 7, Issue 2, pp. 1111-21, (2016) (PubMed).
: "Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility." in: Cell, Vol. 157, Issue 4, pp. 808-22, (2014) (PubMed).
: "Hibiscus sabdariffa leaf polyphenolic extract inhibits LDL oxidation and foam cell formation involving up-regulation of LXRα/ABCA1 pathway." in: Food chemistry, Vol. 141, Issue 1, pp. 397-406, (2013) (PubMed).
: "Anti-atherosclerotic potential of gossypetin via inhibiting LDL oxidation and foam cell formation." in: Toxicology and applied pharmacology, Vol. 272, Issue 2, pp. 313-24, (2013) (PubMed).
: "STIM1 is required for attenuation of PMCA-mediated Ca2+ clearance during T-cell activation." in: The EMBO journal, Vol. 31, Issue 5, pp. 1123-33, (2012) (PubMed).
Synonyms and alternative names related to ATP2B4
ATPase plasma membrane Ca2+ transporting 4 (ATP2B4), ATPase, Ca++ transporting, plasma membrane 4 L homeolog (atp2b4.L), ATPase, Ca++ transporting, plasma membrane 4 (atp2b4), ATPase, Ca++ transporting, plasma membrane 4 (Atp2b4), ATPase plasma membrane Ca2+ transporting 4 (Atp2b4), ATPase plasma membrane Ca2+ transporting 4 (atp2b4), ATP2B1, ATP2B2, atp2b2, atp2b3, ATP2B4, MXRA1, mxra1, PMCA4, pmca4, Pmca4, PMCA4b, pmca4b, PMCA4x, pmca4x, zgc:152801Protein level used designations for ATP2B4
- matrix-remodeling-associated protein 1
- plasma membrane calcium-transporting ATPase 4
- sarcolemmal calcium pump
- ATPase, Ca++ transporting, plasma membrane 3
- plasma membrane calcium ATPase 3
- plasma membrane calcium ATPase
- plasma membrane calcium ATPase 4
- pmca4
- ATPase, Ca++ transporting, plasma membrane 4
- ATPase, Ca++ transporting, plasma membrane 4 ATP synthase, H+ transporting, mitochondrial F1
- plasma membrane Ca2+-ATPases 4
- plasma membrane calcium pump
- plasma membrane calcium-transporting ATPase 4-like
- ATPase, Ca++ transporting, plasma membrane 4 tv2
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