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ATM Products

(Ataxia Telangiectasia Mutated (ATM))
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010].

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Featured ATM Categories

ATM Antibodies

High quality antibodies with extensive validation data.

ATM ELISA Kits

Reliable ELISA kits for a wide range of species.

ATM Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ATM Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, ELISA, FACS, FM
Validations
  • (70)
  • (12)
Cat. No. ABIN6656104
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, FM
Validations
  • (3)
  • (5)
Cat. No. ABIN6657494
Quantity 25 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC, ELISA, IP, IF, FACS, ICC
Validations
  • (7)
Cat. No. ABIN363380
Quantity 0.05 mL
Datasheet Datasheet

Recommended ATM ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6953956
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6953957
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Cell ELISA
Validations
Cat. No. ABIN5526689
Quantity 96 tests
Datasheet Datasheet

Recommended ATM Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1345994
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1345996
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7393904
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our ATM products

Gautam, Stanley, Owen, Bridge: "Localization of the kinase Ataxia Telangiectasia Mutated to Adenovirus E4 mutant DNA replication centers is important for its inhibitory effect on viral DNA accumulation." in: Virology, Vol. 527, pp. 47-56, (2019) (PubMed).

Yin, Xu, Chang, Zeng, Chen, Wang, Groth, Foo, Liang, Hu, Huang: "N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway." in: Molecular cancer, Vol. 18, Issue 1, pp. 11, (2019) (PubMed).

Meister-Broekema, Freilich, Jagadeesan, Rauch, Bengoechea, Motley, Kuiper, Minoia, Furtado, van Waarde, Bird, Rebelo, Zuchner, Pytel, Scherer, Morelli, Carra, Weihl, Bergink, Gestwicki, Kampinga: "Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks." in: Nature communications, Vol. 9, Issue 1, pp. 5342, (2019) (PubMed).

Dworak, Makosa, Chatterjee, Jividen, Yang, Snow, Simke, Johnson, Kelley, Paschal: "A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling." in: Aging cell, Vol. 18, Issue 1, pp. e12851, (2019) (PubMed).

Xu, Ma, Zeng, Zhao, Tao, Chen, Groth, Liang, Hu, Huang: "ATM deficiency promotes progression of CRPC by enhancing Warburg effect." in: Endocrine-related cancer, Vol. 26, Issue 1, pp. 59-71, (2019) (PubMed).

Chen, Chen, Huang, Gu, Qiu, Qian, Shao, Zhang, Hu, Li, He, Zhou, Abdel-Wahab, Zhang, Fu: "The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations." in: Molecular cell, Vol. 69, Issue 3, pp. 412-425.e6, (2019) (PubMed).

Kreis, Gallrein, Rojas-Puente, Mack, Kroon, Dinkel, Willmes, Murk, Tom-Dieck, Schuman, Kirstein, Eickholt: "ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans." in: Nature communications, Vol. 10, Issue 1, pp. 486, (2019) (PubMed).

Li, Mahon, Sweeney, Verschueren, Kantamani, Li, Hennigs, Marciano, Diebold, Abu-Halawa, Elliott, Sa, Guo, Wang, Cao, Guignabert, Sollier, Nickel, Kaschwich, Cimprich, Rabinovitch: "PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis." in: Cell reports, Vol. 26, Issue 5, pp. 1333-1343.e7, (2019) (PubMed).

Rosina, Langone, Giuliani, Cerquone Perpetuini, Reggio, Calderone, Fuoco, Castagnoli, Gargioli, Cesareni: "Osteogenic differentiation of skeletal muscle progenitor cells is activated by the DNA damage response." in: Scientific reports, Vol. 9, Issue 1, pp. 5447, (2019) (PubMed).

Parisotto, Grelet, El Bizri, Dai, Terzic, Eckert, Gargowitsch, Bornert, Metzger: "PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo." in: The Journal of experimental medicine, Vol. 215, Issue 6, pp. 1749-1763, (2019) (PubMed).

Synonyms and alternative names related to ATM

telomere fusion (tefu), ATM serine/threonine kinase L homeolog (atm.L), ATM serine/threonine kinase (atm), ATM serine/threonine kinase (ATM), ataxia telangiectasia mutated (atm), ataxia telangiectasia mutated (EDI_100660), ataxia telangiectasia mutated (CpipJ_CPIJ001772), ataxia telangiectasia mutated (BDBG_08252), ataxia telangiectasia mutated (PAAG_02532), ataxia telangiectasia mutated (MCYG_05088), ataxia telangiectasia mutated (VDBG_06833), ataxia telangiectasia mutated (atm) (ACLA_015700), serine/threonine-protein kinase ATM (LOC5565620), ataxia telangiectasia mutated (MGYG_07634), ataxia telangiectasia mutated (PGTG_14279), ATM serine/threonine kinase (Atm), ataxia telangiectasia mutated (Atm), AI256621, at1, AT1, ATA, ATC, ATD, atdc, ATDC, ATE, ATM, Atm, atm, atm/tefu, C030026E19Rik, CG6535, dATM, Dmel\\CG6535, tef, Tefu, tel1, TEL1, telo1, TELO1, Xatm

Protein level used designations for ATM

  • CG6535-PB
  • ataxia telangiectasia mutated
  • ataxia telengiesctasia mutated
  • ataxia-telangiectasia mutated
  • drosophila ATM
  • tefu-PB
  • chunp9624
  • ataxia telangiectasia mutated (includes complementation groups A, C and D)
  • ataxia telangiectasia mutated protein
  • serine-protein kinase ATM-like
  • ataxia telangiectasia mutated (atm)
  • A-T mutated
  • AT mutated
  • TEL1, telomere maintenance 1, homolog
  • serine-protein kinase ATM
  • Ataxia telangiectasia gene mutated in human beings
  • ataxia telangiectasia mutated homolog
  • A-T mutated homolog
  • ATM (ataxia telangiectasia mutated)
  • ataxia telangiectasia gene mutated in human beings
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