ASL Products
(Argininosuccinate Lyase (ASL))
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This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
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Featured ASL Categories
ASL Antibodies
High quality antibodies with extensive validation data.
ASL ELISA Kits
Reliable ELISA kits for a wide range of species.
ASL Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ASL Antibodies
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Reactivity
Application
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Cat. No.
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Cat. No.
ABIN2856924
Quantity
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Datasheet
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ABIN6137201
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ABIN7144595
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Recommended ASL ELISA Kits
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96 tests
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Mouse
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ABIN1122450
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Rat
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10 μg
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Escherichia coli (E. coli)
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Cat. No.
ABIN7121890
Quantity
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Datasheet
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Reactivity
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Source
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Validations
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ABIN2128038
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Datasheet
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Latest Publications for our ASL products
: "Argininosuccinate lyase interacts with cyclin A2 in cytoplasm and modulates growth of liver tumor cells." in: Oncology reports, Vol. 37, Issue 2, pp. 969-978, (2017) (PubMed).: "Argininosuccinate lyase is a potential therapeutic target in breast cancer." in: Oncology reports, Vol. 34, Issue 6, pp. 3131-9, (2015) (PubMed).
: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." in: Theranostics, Vol. 4, Issue 2, pp. 215-28, (2014) (PubMed).
: "Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma." in: Cell death & disease, Vol. 4, pp. e458, (2013) (PubMed).
: "Understanding the role of argininosuccinate lyase transcript variants in the clinical and biochemical variability of the urea cycle disorder argininosuccinic aciduria." in: The Journal of biological chemistry, Vol. 288, Issue 48, pp. 34599-611, (2013) (PubMed).
: "Argininosuccinate lyase deficiency: mutational spectrum in Italian patients and identification of a novel ASL pseudogene." in: Human mutation, Vol. 28, Issue 7, pp. 694-702, (2007) (PubMed).
: "A novel stop codon mutation (X465Y) in the argininosuccinate lyase gene in a patient with argininosuccinic aciduria." in: The Tohoku journal of experimental medicine, Vol. 198, Issue 2, pp. 119-24, (2003) (PubMed).
Synonyms and alternative names related to ASL
argininosuccinate lyase (ASL), argininosuccinate lyase (Asl), argininosuccinate lyase (asl), argininosuccinate lyase (argH2), argininosuccinate lyase ArgH (argH), argininosuccinate lyase (argH), argininosuccinate lyase (arg7), argininosuccinate lyase (CNC04420), argininosuccinate lyase (STHERM_c13370), adenylosuccinate lyase (Adsl), argininosuccinate lyase L homeolog (asl.L), argininosuccinate lyase (ARG7), 2510006M18Rik, Adl, ASAL, Asl, BA4879, PSPTO0125, zgc:63532Protein level used designations for ASL
- argininosuccinase
- arginosuccinase
- ASAL
- argininosuccinate lyase
- ASase
- adenylosuccinase
- adenylosuccinate lyase 1
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