ASK1 Products
(Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))
Categories
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells\; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008].
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Featured ASK1 Categories
ASK1 Antibodies
High quality antibodies with extensive validation data.
ASK1 ELISA Kits
Reliable ELISA kits for a wide range of species.
ASK1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ASK1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Cow, Human, Mouse, Rat
Application
WB, ELISA, IHC (p), FACS
Validations
- (2)
- (5)
Cat. No.
ABIN683128
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA, ICC, FACS
Validations
- (1)
- (5)
Cat. No.
ABIN969273
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (1)
- (4)
Cat. No.
ABIN6255571
Quantity
100 μL
Datasheet
Datasheet
Recommended ASK1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6957867
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968654
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968655
Quantity
96 tests
Datasheet
Datasheet
Recommended ASK1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124004
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310221
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5508821
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our ASK1 products
: "Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells." in: Cells, Vol. 8, Issue 10, (2020) (PubMed).: "Endoplasmic Reticulum Stress Is Involved in Stress-Induced Hypothalamic Neuronal Injury in Rats via the PERK-ATF4-CHOP and IRE1-ASK1-JNK Pathways." in: Frontiers in cellular neuroscience, Vol. 13, pp. 190, (2019) (PubMed).
: "Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain." in: Journal of neuroinflammation, Vol. 16, Issue 1, pp. 83, (2019) (PubMed).
: "Dual function of peroxiredoxin I in lipopolysaccharide-induced osteoblast apoptosis via reactive oxygen species and the apoptosis signal-regulating kinase 1 signaling pathway." in: Cell death discovery, Vol. 4, pp. 47, (2018) (PubMed).
: "Differential expression of survival proteins during decreased intracellular oxygen tension in brain endothelial cells of grey mullets." in: Marine pollution bulletin, Vol. 115, Issue 1-2, pp. 421-428, (2017) (PubMed).
: "Differential regulation of pro- and antiapoptotic proteins in fish adipocytes during hypoxic conditions." in: Fish physiology and biochemistry, Vol. 42, Issue 3, pp. 919-34, (2016) (PubMed).
: "Peroxiredoxin 1 Promotes Pancreatic Cancer Cell Invasion by Modulating p38 MAPK Activity." in: Pancreas, Vol. 44, Issue 2, pp. 331-40, (2015) (PubMed).
: "Calcium/Ask1/MKK7/JNK2/c-Src signalling cascade mediates disruption of intestinal epithelial tight junctions by dextran sulfate sodium." in: The Biochemical journal, Vol. 465, Issue 3, pp. 503-15, (2015) (PubMed).
: "Ginsenoside Rd inhibits apoptosis following spinal cord ischemia/reperfusion injury." in: Neural regeneration research, Vol. 9, Issue 18, pp. 1678-87, (2014) (PubMed).
: "Heat-shock protein 70 modulates apoptosis signal-regulating kinase 1 in stressed hepatocytes of Mugil cephalus." in: Fish physiology and biochemistry, Vol. 40, Issue 5, pp. 1573-85, (2014) (PubMed).
Synonyms and alternative names related to ASK1
mitogen-activated protein kinase kinase kinase 5 (MAP3K5), mitogen-activated protein kinase kinase kinase 5 (MAPKKK5), mitogen-activated protein kinase kinase kinase 5 (Map3k5), mitogen-activated protein kinase kinase kinase 5 (map3k5), 7420452D20Rik, ASK, ASK1, Ask1, MAPKKK5, MEKK5, Mekk5, mitogen-activated protein kinase kinase kinase 5, MUD21.11, MUD21_11, RGD1306565Protein level used designations for ASK1
- ASK-1
- MAP/ERK kinase kinase 5
- MAPK/ERK kinase kinase 5
- MEK kinase 5
- MEKK 5
- apoptosis signal regulating kinase 1
- apoptosis signal-regulating kinase 1
- mitogen activated protein kinase kinase kinase 5
- mitogen-activated protein kinase kinase kinase 5
- mitogen-activated protein kinase kinase kinase 5 pseudogene
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