Cytoskeleton Marker
The cytoskeleton is a dynamic network of protein filaments that stabilizes cell structure, defines cell shape, and enables critical processes such as intracellular transport, cell migration, and signal transduction. It is composed of three main components: actin filaments, microtubules, and intermediate filaments, each characterized by specific proteins.
Cytoskeletal markers such as actin filaments, microtubules, and intermediate filaments – including vimentin or cytokeratin – as well as myosin are essential tools for studying the structure and function of the cytoskeleton. Actin filaments play a central role in cell migration and shaping, microtubules are crucial for intracellular transport and organelle organization, while intermediate filaments like vimentin and cytokeratin contribute to mechanical stability and signal transduction. Myosin, a motor protein, mediates processes such as cell contraction and the transport of organelles along filaments.
The investigation of the cytoskeleton using specific markers has broad applications in biomedical research. Cytoskeleton markers are essential in studying the mechanisms of cell migration and invasion, processes critical for cancer metastasis. Actin filaments and myosin play pivotal roles in the formation of lamellipodia and filopodia, structures that enable tumor cells to migrate through the extracellular matrix. Microtubules and intermediate filaments, such as vimentin, are used to investigate cytoskeletal reorganization during epithelial-to-mesenchymal transition (EMT), a key step in metastatic progression. These studies provide insights into potential therapeutic targets to inhibit tumor spread. Cytoskeletal markers are also critical for understanding the pathophysiology of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. Microtubule-associated proteins, along with intermediate filaments like neurofilament proteins, are used to investigate axonal transport disruptions, neuronal structural integrity, and protein aggregation. These markers also facilitate the study of cytoskeletal defects in neurons, which contribute to disease progression and neurodegeneration, offering potential avenues for the development of targeted therapies.
antibodies-online offers a comprehensive range of high-quality antibodies against cytoskeletal markers such as actin, microtubules, intermediate filaments (e.g., vimentin and cytokeratin), and myosin. Our antibodies are carefully validated to ensure reliable and reproducible results that meet the demands of modern scientific research. With a focus on quality and precision, we support researchers in gaining new insights with confidence.
