SARS-CoV-2 Non-Structural Proteins
SARS-CoV-2 proteins can be grouped in two major classes, structural and nonstrcutural proteins (NSPs). While structural proteins, either hold the RNA genome or are built into the viral envelope, a nonstructural protein encoded by a virus is expressed in infected cells, but not incorporated into the virion particle. NSPs include the various enzymes and transcription factors the virus uses to replicate itself, such as a viral protease, an RNA replicase and some means to control the host.
After host cell infection SARS-CoV-2 polyproteins pp1a and pp1ab, are translated which are cleaved by the Papain-like protease (Plpro) and 3C-like protease (3CLpro). Cleaved proteins are funcional NSPs like helicase or the RNA-dependent RNA polymerase (RdRp) that catalyzes the replication of RNA from an RNA template and is responsible for the replication of SARS-CoV-2 structural protein RNA. The RNA helicase helps to unwind dsRNA.
NSP1
NSP2
NSP3
NSP4
NSP5
NSP6
NSP7
NSP8
NSP9
NSP10
NSP12
NSP13
NSP14
NSP15
NSP16
Heterodimer Proteins
ORFs
Goal-oriented, time line driven scientist, proficiently trained in different academic institutions in Germany, France and the USA. Experienced in the life sciences e-commerce environment with a focus on product development and customer relation management.
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