Stem Cell Markers

Pluripotent stem cells show great potential in the realm of regenerative medicine due to their capacity to proliferate indefinitely and differentiate into various cell types, including neurons, heart cells, pancreatic cells, and liver cells. They serve as a singular cell source capable of replacing those lost to damage or disease.

The most widely recognized type of pluripotent stem cell is the embryonic stem cell. Nevertheless, controversy surrounds their use since generating embryonic stem cells involves the manipulation or destruction of pre-implantation stage embryos. Recent advancements allow for the derivation of patient-matched embryonic stem cell lines through somatic cell nuclear transfer (SCNT).

Induced pluripotent stem cells (iPSCs) offer an alternative approach, being directly derived from adult tissues. They not only eliminate the need for embryos but can be produced in a patient-specific manner, enabling each individual to have their own pluripotent stem cell line. This potential for an unlimited supply of autologous cells holds promise for generating transplants without the concern of immune rejection.

While the safety of iPSC technology for therapeutic transplants is still under evaluation, iPSCs are currently playing a crucial role in personalized drug discovery and enhancing our understanding of the individualized basis of diseases.