CNS Cell Markers

Neural stem cells acting as a source of various cell types are a subpopulation of cells that can self-renewal and proliferate identical cells. They are multipotent to generate diversity neural lineages, encompassing neurons, astrocytes, and oligodendrocytes. Central nervous system (CNS) cell markers are fundamental in elucidating the functions of different neural cell types and their involvement in various neurological diseases and disorders. Researchers and clinicians rely on these antibodies to gain insights into the cellular composition of the central nervous system and to develop therapies and diagnostic tools for conditions such as neurodegenerative diseases, brain injuries, and neuroinflammatory disorders. These antibodies are used in various experimental techniques, including immunohistochemistry and immunofluorescence, to visualize and study the distribution of specific cell types within the CNS. antibodies-online offers an outstanding selection of marker antibodies and kits for detection of neurons, microglia and astrocytes. We also offer proteins, peptides and reagents for neuroscience research.

Types of cell markers

The investigation of the basic processes in the CNS is of high relevance for research on neurodegenerative diseases. antibodies-online aims to support research with hand-picked, high-quality antibodies and kits against many important cell type markers.

Neural Progenitor Cells

Neural progenitor cells (NPCs)" are the progenitor cells of the CNS that give rise to many, if not all, of the glial and neuronal cell types that populate the CNS.⁽²⁾ Please see the highlighted antibodies below.

Microglia

Although microglia were first described as ramified brain-resident phagocytes, research conducted over the past century has expanded considerably upon this narrow view and ascribed many functions to these dynamic CNS inhabitants. Microglia are now considered among the most versatile cells in the body, possessing the capacity to morphologically and functionally adapt to their ever-changing surroundings.⁽³⁾ Please see the highlighted antibodies below.

Astrocytes

Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They contiguously tile the entire central nervous system (CNS) and exert many essential complex functions in the healthy CNS.⁽⁴⁾ Please see the highlighted antibodies below.

Immature Neurons

Immature neurons, also known as neural precursor cells or neuroblasts, represent an early stage in the development of the nervous system. These cells have not yet fully differentiated into mature, functional neurons and retain the capacity for further development. Immature neurons are often found in specific regions of the brain, such as the subventricular zone and the dentate gyrus of the hippocampus, where they can contribute to neurogenesis and brain plasticity.

Oligodendrocytes

Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are the end product of a cell lineage which has to undergo a complex and precisely timed program of proliferation, migration, differentiation, and myelination to finally produce the insulating sheath of axons.⁽⁵⁾ Please see the highlighted antibodies below.

Mature Neurons

Mature neurons promote survival at all costs by employing multiple, often redundant, strategies to prevent cell death by apoptosis. This dramatic shift from permitting cell death to ensuring cellular survival is critical, as these post-mitotic cells must provide neuronal circuitry for an organism's entire lifetime.⁽⁶⁾ Please see the highlighted antibodies below.

References

1. Zhang, Jiao: "Molecular Biomarkers for Embryonic and Adult Neural Stem Cell and Neurogenesis." in: BioMed research international, Vol. 2015, pp. 727542, (2016) (PubMed).
2. Martínez-Cerdeño, Noctor: "Neural Progenitor Cell Terminology." in: Frontiers in neuroanatomy, Vol. 12, pp. 104, (2018) (PubMed).
3. Nayak, Roth, McGavern: "Microglia development and function." in: Annual review of immunology, Vol. 32, pp. 367-402, (2014) (PubMed).
4. Sofroniew, Vinters: "Astrocytes: biology and pathology." in: Acta neuropathologica, Vol. 119, Issue 1, pp. 7-35, (2010) (PubMed).
5. Bradl, Lassmann: "Oligodendrocytes: biology and pathology." in: Acta neuropathologica, Vol. 119, Issue 1, pp. 37-53, (2010) (PubMed).
6. Kole, Annis, Deshmukh: "Mature neurons: equipped for survival." in: Cell death & disease, Vol. 4, pp. e689, (2014) (PubMed).

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Master of Science in engineering. 12+ years of experience in marketing and e-commerce in the life science sector.

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