ARNT Products
(Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT))
Categories
The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1\;12)(q21\;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010].
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Featured ARNT Categories
ARNT Antibodies
High quality antibodies with extensive validation data.
ARNT ELISA Kits
Reliable ELISA kits for a wide range of species.
ARNT Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ARNT Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p), RNAi
Validations
- (7)
Cat. No.
ABIN559953
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (4)
Cat. No.
ABIN513506
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (4)
Cat. No.
ABIN6260045
Quantity
100 μL
Datasheet
Datasheet
Recommended ARNT ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6953934
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965029
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953933
Quantity
96 tests
Datasheet
Datasheet
Recommended ARNT Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1345671
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345673
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7397531
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ARNT products
: "Molecular cloning and characterization of two ARNT (ARNT-1 and ARNT-2) genes in Atlantic croaker and their expression during coexposure to hypoxia and PCB77." in: Environmental toxicology, Vol. 34, Issue 2, pp. 160-171, (2019) (PubMed).: "Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin." in: EMBO reports, Vol. 20, Issue 1, (2019) (PubMed).
: "MITF controls the TCA cycle to modulate the melanoma hypoxia response." in: Pigment cell & melanoma research, (2019) (PubMed).
: "Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 6, pp. E1239-E1248, (2018) (PubMed).
: "AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle." in: Nature communications, Vol. 9, Issue 1, pp. 540, (2018) (PubMed).
: "NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis." in: Cancer discovery, Vol. 8, Issue 7, pp. 850-865, (2018) (PubMed).
: "Anti-inflammatory Effects of Phyllanthus emblica L on Benzopyrene-Induced Precancerous Lung Lesion by Regulating the IL-1β/miR-101/Lin28B Signaling Pathway." in: Integrative cancer therapies, Vol. 16, Issue 4, pp. 505-515, (2018) (PubMed).
: "Metastasis-Associated Protein 1 Deficiency Results in Compromised Pulmonary Alveolar Capillary Angiogenesis in Mice." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 23, pp. 3932-3941, (2018) (PubMed).
: "TLR4 promotes the expression of HIF-1α by triggering reactive oxygen species in cervical cancer cells in vitro-implications for therapeutic intervention." in: Molecular medicine reports, Vol. 17, Issue 2, pp. 2229-2238, (2018) (PubMed).
: "Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer." in: Cell reports, Vol. 25, Issue 13, pp. 3721-3732.e6, (2018) (PubMed).
Synonyms and alternative names related to ARNT
aryl hydrocarbon receptor nuclear translocator (ARNT), aryl hydrocarbon receptor nuclear translocator (Arnt), aryl hydrocarbon receptor nuclear translocator (arnt), aryl hydrocarbon receptor nuclear translocator S homeolog (arnt.S), ARNT, arnt.2, Arnt1, arnt1, bHLHe2, D3Ertd557e, Drnt, ESTM42, HIF-1-beta, HIF-1beta, hif-1beta, HIF1-beta, HIF1B, Hif1b, hif1b, HIF1BETA, hif1beta, MGC68805, mKIAA4051, TANGO, tango, W08714, xArnt, zgc:136664Protein level used designations for ARNT
- class E basic helix-loop-helix protein 2
- dioxin receptor, nuclear translocator
- hypoxia-inducible factor 1, beta subunit
- ARNT protein
- HIF-1 beta
- HIF-1-beta
- HIF1-beta
- aryl hydrocarbon receptor nuclear translocator
- hypoxia-inducible factor 1 beta
- hypoxia-inducible factor 1-beta
- Aryl hydrocarbon receptor nuclear translocator 1
- ARNT1
- aryl hydrocarbon receptor nuclear translocater
- aryl hydrocarbon receptor nuclear translocator 2
- rtARNT
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