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APPL2 Products

(Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))

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The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011].

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Featured APPL2 Categories

APPL2 Antibodies

High quality antibodies with extensive validation data.

APPL2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended APPL2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (4)
Cat. No. ABIN527415
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (1)
  • (3)
Cat. No. ABIN527414
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IF, IHC
Validations
  • (2)
Cat. No. ABIN7149505
Quantity 100 μg
Datasheet Datasheet

Recommended APPL2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6964611
Quantity 96 tests
Datasheet Datasheet

Recommended APPL2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7121696
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1345412
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1345410
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our APPL2 products

Gaspar, Muñoz, Kuga, Nakandakari, Crisol, Lenhare, Breda, Botezelli, SantAna, da Silva, Cintra, de Moura, Ropelle, Pauli: "Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice." in: The European journal of neuroscience, (2019) (PubMed).

Canciglieri, Kuga, Muñoz, Gaspar, da Rocha, Breda, Anaruma, Minuzzi, da Silva, Cintra, de Moura, Ropelle, Pauli: "The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle." in: Life sciences, Vol. 210, pp. 209-213, (2018) (PubMed).

Gaspar, Muñoz, Formigari, Kuga, Nakandakari, Botezelli, da Silva, Cintra, de Moura, Ropelle, Pauli: "Acute physical exercise increases the adaptor protein APPL1 in the hypothalamus of obese mice." in: Cytokine, Vol. 110, pp. 87-93, (2018) (PubMed).

Cleasby, Lau, Polkinghorne, Patel, Leslie, Turner, Cooney, Xu, Kraegen: "The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway." in: The Journal of endocrinology, Vol. 210, Issue 1, pp. 81-92, (2011) (PubMed).

Synonyms and alternative names related to APPL2

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (Appl2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog (appl2.L), adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (appl2), adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2), APPL2, Dip3b, dip13b, DIP13B, MGC84621, RGD1563028

Protein level used designations for APPL2

  • DCC-interacting protein 13-beta
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
  • amyloid beta (A4) precursor-like protein 2
  • DIP13 beta
  • adapter protein containing PH domain, PTB domain and leucine zipper motif 2
  • Dip3 beta
  • dip13-beta
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