APP Products
(Amyloid beta (A4) Precursor Protein (APP))
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This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured APP Categories
APP Antibodies
High quality antibodies with extensive validation data.
APP ELISA Kits
Reliable ELISA kits for a wide range of species.
APP Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended APP Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), ICC, IHC (fro)
Validations
- (7)
- (1)
Cat. No.
ABIN2855011
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, IF, FM
Validations
- (1)
- (7)
- (2)
Cat. No.
ABIN95037
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (4)
- (1)
Cat. No.
ABIN3020680
Quantity
100 μL
Datasheet
Datasheet
Recommended APP ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6953681
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6999550
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953682
Quantity
96 tests
Datasheet
Datasheet
Recommended APP Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7092740
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345399
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345401
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our APP products
: "Amyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma." in: Cell death & disease, Vol. 15, Issue 1, pp. 35, (2024) (PubMed).: "Aβ∗56 is a stable oligomer that impairs memory function in mice." in: iScience, Vol. 27, Issue 3, pp. 109239, (2024) (PubMed).
: "The divergent effects of astrocyte ceruloplasmin on learning and memory function in young and old mice." in: Cell death & disease, Vol. 13, Issue 11, pp. 1006, (2022) (PubMed).
: "Plasmonic nanoparticle amyloid corona for screening Aβ oligomeric aggregate-degrading drugs." in: Nature communications, Vol. 12, Issue 1, pp. 639, (2021) (PubMed).
: "Iron potentiates microglial interleukin-1β secretion induced by amyloid-β." in: Journal of neurochemistry, Vol. 154, Issue 2, pp. 177-189, (2020) (PubMed).
: "Cerebrovascular miRNAs correlate with the clearance of Aβ through perivascular route in younger 3xTg-AD mice." in: Brain pathology (Zurich, Switzerland), Vol. 30, Issue 1, pp. 92-105, (2020) (PubMed).
: "Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer's Disease-like Neurotoxicity." in: Scientific reports, Vol. 7, Issue 1, pp. 7497, (2019) (PubMed).
: "Multifunctionalized Reduced Graphene Oxide Biosensors for Simultaneous Monitoring of Structural Changes in Amyloid-β 40." in: Sensors (Basel, Switzerland), Vol. 18, Issue 6, (2018) (PubMed).
: "Polarization of Microglia to the M2 Phenotype in a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Manner Attenuates Axonal Injury Induced by Traumatic Brain Injury in Mice." in: Journal of neurotrauma, (2018) (PubMed).
: "β-Sheet Breaker Peptide-HPYD for the Treatment of Alzheimer's Disease: Primary Studies on Behavioral Test and Transcriptional Profiling." in: Frontiers in pharmacology, Vol. 8, pp. 969, (2018) (PubMed).
Synonyms and alternative names related to APP
amyloid beta precursor protein (APP), amyloid beta (A4) precursor protein (APP), amyloid beta precursor protein (app), beta amyloid protein precursor-like (Appl), amyloid beta precursor protein (App), amyloid beta (A4) precursor protein (App), amyloid beta (A4) precursor protein a (appa), amyloid beta precursor protein L homeolog (app.L), AAA, aaa, ABETA, abeta, Abeta, ABPP, abpp, Abpp, AD1, ad1, Adap, Ag, APP, app, APP-like, APPI, appi, APPL, appl, BcDNA:GH04413, betaApp, CG7727, CTFgamma, ctfgamma, CVAP, cvap, Cvap, Dmel\\CG7727, E030013M08Rik, EG:65F1.5, PN-II, PN2, pn2, wu:fj34d10, wu:fk65e12, zgc:85740Protein level used designations for APP
- alzheimer disease amyloid protein
- amyloid beta A4 protein
- beta-amyloid peptide
- cerebral vascular amyloid peptide
- peptidase nexin-II
- preA4
- protease nexin-II
- amyloid protein
- ABPP
- alzheimer disease amyloid A4 protein homolog
- amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
- Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimers disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4)
- amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease)
- amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease)
- beta-amyloid precursor protein
- Appl-PA
- Appl-PB
- Appl-PC
- Appl-PD
- Appl-PE
- Appl-PF
- CG7727-PA
- CG7727-PB
- CG7727-PC
- CG7727-PD
- CG7727-PE
- CG7727-PF
- amyloid precursor protein
- amyloid precursor protein-like
- beta-amyloid-protein-precursor-like
- AG
- amyloid A4
- amyloidogenic glycoprotein
- appican
- protease nexin II
- amyloid beta precursor protein a
- beta-amyloid precursor protein A
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- Apolipoprotein L 2
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- Apolipoprotein D
- Apolipoprotein C-II
- Apolipoprotein A-I
- Apolipoprotein A
- APOLD1
- APOL6
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