APEX1 Products
(Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
Categories
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene\; all encode the same protein. [provided by RefSeq, Jul 2008].
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Featured APEX1 Categories
APEX1 Antibodies
High quality antibodies with extensive validation data.
APEX1 ELISA Kits
Reliable ELISA kits for a wide range of species.
APEX1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended APEX1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS
Validations
- (8)
Cat. No.
ABIN5611191
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p)
Validations
- (6)
Cat. No.
ABIN513392
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Dog, Human, Monkey
Application
WB, IHC, IHC (p)
Validations
- (8)
Cat. No.
ABIN1490625
Quantity
100 μL
Datasheet
Datasheet
Recommended APEX1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964918
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953823
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6974754
Quantity
96 tests
Datasheet
Datasheet
Recommended APEX1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1345305
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121878
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121879
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our APEX1 products
: "Targeting Histone Chaperone FACT Complex Overcomes 5-Fluorouracil Resistance in Colon Cancer." in: Molecular cancer therapeutics, Vol. 19, Issue 1, pp. 258-269, (2020) (PubMed).: "The long noncoding RNA ROCKI regulates inflammatory gene expression." in: The EMBO journal, Vol. 38, Issue 8, (2019) (PubMed).
: "Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination." in: The Journal of biological chemistry, Vol. 294, Issue 13, pp. 5198-5207, (2019) (PubMed).
: "The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated ..." in: Molecular and cellular biology, Vol. 39, Issue 9, (2019) (PubMed).
: "Serum AP-endonuclease 1 (sAPE1) as novel biomarker for hepatocellular carcinoma." in: Oncotarget, Vol. 10, Issue 3, pp. 383-394, (2019) (PubMed).
: "Inactivation of XPF Sensitizes Cancer Cells to Gemcitabine." in: Journal of nucleic acids, Vol. 2019, pp. 6357609, (2019) (PubMed).
: "APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC." in: Journal of experimental & clinical cancer research : CR, Vol. 38, Issue 1, pp. 309, (2019) (PubMed).
: "The endonuclease APE1 processes miR-92b formation, thereby regulating expression of the tumor suppressor LDLR in cervical cancer cells." in: Therapeutic advances in medical oncology, Vol. 11, pp. 1758835919855859, (2019) (PubMed).
: "ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1." in: International journal of molecular sciences, Vol. 20, Issue 13, (2019) (PubMed).
: "Decreased APE-1 by Nitroxoline Enhances Therapeutic Effect in a Temozolomide-resistant Glioblastoma: Correlation with Diffusion Weighted Imaging." in: Scientific reports, Vol. 9, Issue 1, pp. 16613, (2019) (PubMed).
Synonyms and alternative names related to APEX1
apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1), APEX nuclease (multifunctional DNA repair enzyme) 1 (apex1), APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog (apex1.L), DNA-(apurinic or apyrimidinic site) lyase (CNG03640), DNA-(apurinic or apyrimidinic site) lyase (CNH01280), DNA-(apurinic or apyrimidinic site) lyase (nth), DNA-(apurinic or apyrimidinic site) lyase (Spirs_4119), DNA-(apurinic or apyrimidinic site) lyase (Palpr_0103), apurinic/apyrimidinic endodeoxyribonuclease 1 (Apex1), apurinic/apyrimidinic endonuclease 1 (Apex1), APE, APE1, APEN, APEX, Apex, apex1, apex1a, APX, BAP1, HAP1, hm:zehn1532, MGC76280, MGC78928, MGC79645, REF-1, Ref-1, REF1, wu:fc13d11, zgc:66204Protein level used designations for APEX1
- DNA-(apurinic or apyrimidinic site) lyase
- APEX nuclease 1
- APEX nuclease (multifunctional DNA repair enzyme) 1
- AP endonuclease class I
- AP lyase
- apurinic-apyrimidinic endonuclease 1
- apurinic/apyrimidinic (abasic) endonuclease
- deoxyribonuclease (apurinic or apyrimidinic)
- protein REF-1
- redox factor-1
- AP endonuclease 1
- APEN
- apurinic/apyrimidinic endonuclease 1
- apurinic/apyrimidinic endonuclease
- zap1
- Apurinic-apyrimidinic endonuclease 1
- Redox factor-1
- APEX nuclease
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