APAF1 Products
(Apoptotic Peptidase Activating Factor 1 (APAF1))
Categories
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Featured APAF1 Categories
APAF1 Antibodies
High quality antibodies with extensive validation data.
APAF1 ELISA Kits
Reliable ELISA kits for a wide range of species.
APAF1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended APAF1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (7)
Cat. No.
ABIN1678685
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
- (5)
Cat. No.
ABIN7433081
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, ICC, FACS
Validations
- (5)
Cat. No.
ABIN5611196
Quantity
100 μL
Datasheet
Datasheet
Recommended APAF1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964972
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964971
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953881
Quantity
96 tests
Datasheet
Datasheet
Recommended APAF1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345275
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7411675
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7393076
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our APAF1 products
: "Optimization of Experimental Variables Influencing Apoptosome Biosensor in HEK293T Cells." in: Sensors (Basel, Switzerland), Vol. 20, Issue 6, (2020) (PubMed).: "A new split-luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation." in: FEBS open bio, Vol. 9, Issue 7, pp. 1194-1203, (2020) (PubMed).
: "Apoptosome formation upon overexpression of native and truncated Apaf-1 in cell-free and cell-based systems." in: Archives of biochemistry and biophysics, Vol. 642, pp. 46-51, (2019) (PubMed).
: "LY333531, a PKCβ inhibitor, attenuates glomerular endothelial cell apoptosis in the early stage of mouse diabetic nephropathy via down-regulating swiprosin-1." in: Acta pharmacologica Sinica, Vol. 38, Issue 7, pp. 1009-1023, (2018) (PubMed).
: "Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma." in: Nature medicine, Vol. 21, Issue 9, pp. 1060-4, (2015) (PubMed).
: "Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer." in: Virchows Archiv : an international journal of pathology, Vol. 467, Issue 5, pp. 563-70, (2015) (PubMed).
: "Human interleukin 23 receptor induces cell apoptosis in mammalian cells by intrinsic mitochondrial pathway associated with the down-regulation of RAS/mitogen-activated protein kinase and signal ..." in: International journal of molecular sciences, Vol. 14, Issue 12, pp. 24656-69, (2014) (PubMed).
: "[Intralobar sequestration in elderly patient, report of a case]" in: Kyobu geka. The Japanese journal of thoracic surgery, Vol. 61, Issue 9, pp. 812-5, (2008) (PubMed).
: "Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1." in: Molecular cell, Vol. 25, Issue 2, pp. 181-92, (2007) (PubMed).
: "Mechanical aspects of apoptosome assembly." in: Current opinion in cell biology, Vol. 18, Issue 6, pp. 677-84, (2006) (PubMed).
Synonyms and alternative names related to APAF1
Death-associated APAF1-related killer (Dark), apoptotic peptidase activating factor 1 L homeolog (apaf1.L), apoptotic peptidase activating factor 1 (apaf1), apoptotic peptidase activating factor 1 (APAF1), apoptotic peptidase activating factor 1 (Apaf1), 6230400I06Rik, anon-53Fa, Apaf-1, apaf-1, APAF-1, APAF1, Apaf1, apaf1, Apaf1l, arc, ARK, ark, CED4, CG6829, D-Apaf-1, dapaf, Dapaf-1, dAPAF-1, dApaf-1, dapaf-1, dApaf-1/DARK/HAC-1, Dapaf-1/HAC-1, dapaf-1L, dapaf-1S, dApaf1, DARK, Dark, dArk, dark, Dark/Apaf-I, dark/dapaf-1/hac-1, Dark/Dapaf-1/HAC1, Dark/Hac-1/dApaf-1, dark/hac-1/dapaf-1, Dark/Hac-1/dApaf1, Dmel\\CG6829, fog, Hac-1, hac-1, Hac-1/Dark, Hac1, hac1, l(2)SH0173, mKIAA0413, T1, zgc:136543Protein level used designations for APAF1
- Apaf-1 related
- Apaf-1 related killer
- Apaf-1-related killer
- Ark-PA
- Ark-PB
- CG6829-PA
- CG6829-PB
- apaf1-related killer
- dark
- drosophila Apaf-1-related killer
- lethal (2) SH0173
- transcription unit 1
- apoptotic peptidase activating factor 1
- apoptotic protease-activating factor 1-like
- apoptotic protease-activating factor 1
- apoptotic protease activating factor 1
- forebrain overgrowth
- apaf-1
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