Aox3 Proteins
(Aldehyde Oxidase 3 (AOX3))
Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as benzaldehyde, retinal and pyridoxal. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. Is a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also catalyzes nitric oxide (NO) production; under anaerobic conditions, reduces nitrite to NO with NADH or aldehyde as electron donor, but under aerobic conditions, NADH is the preferred substrate. These reactions may be catalyzed by several isozymes. {ECO:0000269|PubMed:17353002, ECO:0000269|PubMed:19801639}.
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Recommended Aox3 Proteins
Synonyms and alternative names related to Aox3
aldehyde oxidase 3 (Aox3), 1200011D03Rik, AI326299, Aoh1, Aoh2Protein level used designations for Aox3
- aldehyde oxidase 1
- aldehyde oxidase structural homolog 2
- Aldehyde oxidase homolog 1
- Azaheterocycle hydroxylase 3
- aldehyde oxidase 3
- aldehyde oxidase homolog 1
- azaheterocycle hydroxylase 3
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