VAV1 antibody (AA 121-324)

Catalog No. ABIN969581

Product Details anti-VAV1 Antibody

Target: VAV1 (Vav 1 Oncogene (VAV1))

Binding Specificity: AA 121-324

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This VAV1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purpose: VAV1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.

Clone: 2E11

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-VAV1 antibody (ABIN969581)

Bertagnolo, Nika, Brugnoli, Bonora, Grassilli, Pinton, Capitani: "Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells." in: Cell and tissue research, Vol. 345, Issue 1, pp. 163-75, (2011) (PubMed).

Yin, Wan, Li, Du, Zhang, Zhou, Cao: "The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells." in: Acta pharmacologica Sinica, Vol. 32, Issue 1, pp. 99-107, (2011) (PubMed).

Target Details for VAV1

Target: VAV1 (Vav 1 Oncogene (VAV1))

Alternative Name: VAV1 (VAV1 Products)

Synonyms: VAV antibody, Vav antibody, vav-T antibody, vav guanine nucleotide exchange factor 1 antibody, vav 1 oncogene antibody, vav guanine nucleotide exchange factor 1 L homeolog antibody, VAV1 antibody, Vav1 antibody, vav1.L antibody

Background:

Description: The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

Aliases: VAV

Molecular Weight: 98.3kDa

Gene ID: 7409

HGNC: 7409

UniProt: P15498

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, BCR Signaling