PPP2R4 antibody

Catalog No. ABIN969557

Product Details anti-PPP2R4 Antibody

Target: PPP2R4 (Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PPP2R4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purpose: PPP2R4 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PPP2R4 expressed in E. Coli.

Clone: 4D9

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PPP2R4 antibody (ABIN969557)

Yoon, Jun, Park, Jun Yoo, Moon, Soon Baik, Kim, Kim, Kim, Koh, Taek Lee, You: "Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal." in: Stem cells (Dayton, Ohio), Vol. 28, Issue 5, pp. 874-84, (2010) (PubMed).

Singh, Ye, Bucur, Zhu, Tanya Santos, Rabinovitz, Wei, Gao, Hahn, Khosravi-Far: "Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT." in: Molecular biology of the cell, Vol. 21, Issue 6, pp. 1140-52, (2010) (PubMed).

Target Details for PPP2R4

Target: PPP2R4 (Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4))

Alternative Name: PPP2R4 (PPP2R4 Products)

Synonyms: PP2A antibody, PR53 antibody, PTPA antibody, 2610042B21Rik antibody, C77440 antibody, N28142 antibody, PTPRA antibody, Ppp2r4 antibody, fc23d07 antibody, ppp2r4 antibody, wu:fc23d07 antibody, zgc:92766 antibody, pp2a antibody, ppp2r4.L antibody, pr53 antibody, ptpa antibody, protein phosphatase 2 phosphatase activator antibody, protein phosphatase 2 protein activator antibody, protein phosphatase 2 phosphatase activator L homeolog antibody, PTPA antibody, Ptpa antibody, ptpa antibody, ptpa.L antibody

Background:

Description: Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.

Aliases: PP2A, PR53, PTPA

Molecular Weight: 41kDa

Gene ID: 5524

HGNC: 5524

UniProt: Q15257

Pathways: PI3K-Akt Signaling, M Phase, Hepatitis C, Toll-Like Receptors Cascades