NOS2 antibody

Catalog No. ABIN969551

Product Details anti-NOS2 Antibody

Target: NOS2 (Nitric Oxide Synthase 2, Inducible (NOS2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NOS2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Purpose: NOS2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human NOS2 expressed in E. Coli.

Clone: 4E5

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-NOS2 antibody (ABIN969551)

Huang, Ratovitski: "Phosphorylated TP63 induces transcription of RPN13, leading to NOS2 protein degradation." in: The Journal of biological chemistry, Vol. 285, Issue 53, pp. 41422-31, (2010) (PubMed).

Granath, Norrby-Teglund, Uddman, Cardell: "Reduced iNOS expression in adenoids from children with otitis media with effusion." in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, Vol. 21, Issue 8, pp. 1151-6, (2010) (PubMed).

Target Details for NOS2

Target: NOS2 (Nitric Oxide Synthase 2, Inducible (NOS2))

Alternative Name: NOS2 (NOS2 Products)

Synonyms: HEP-NOS antibody, INOS antibody, NOS antibody, NOS2A antibody, NOS-II antibody, Nos-2 antibody, Nos2a antibody, i-NOS antibody, iNOS antibody, iNos antibody, NOS2a antibody, NOS2 antibody, BmNOS2 antibody, Nsl antibody, nos2 antibody, nitric oxide synthase 2 antibody, nitric oxide synthase 2, inducible antibody, inducible nitric oxide synthase antibody, inducible nitric-oxide synthase antibody, nanos C2HC-type zinc finger 2 antibody, NOS2 antibody, Nos2 antibody, nos2 antibody, LOC396821 antibody, NANOS2 antibody

Background:

Description: Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17.

Aliases: NOS, INOS, NOS2A, HEP-NOS

Molecular Weight: 131kDa

Gene ID: 4843

HGNC: 4843

UniProt: P35228

Pathways: Retinoic Acid Receptor Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Inositol Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process