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MELK antibody (AA 637-651)

MELK Reactivity: Human ELISA, IHC, ICC, FACS Host: Mouse Monoclonal 2G2 unconjugated
Catalog No. ABIN969538
  • Target See all MELK Antibodies
    MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))
    Binding Specificity
    • 15
    • 8
    • 8
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 637-651
    Reactivity
    • 61
    • 18
    • 14
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    Human
    Host
    • 61
    • 4
    • 1
    Mouse
    Clonality
    • 61
    • 5
    Monoclonal
    Conjugate
    • 35
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MELK antibody is un-conjugated
    Application
    • 39
    • 28
    • 13
    • 13
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Purpose
    MELK Antibody
    Sequence
    VYKRLVEDIL SSCKV
    Purification
    Purified antibody
    Immunogen
    Synthesized peptide of human MELK(AA: 637-651:C-VYKRLVEDILSSCKV).
    Clone
    2G2
    Isotype
    IgG2a
  • Application Notes

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/200 - 1/1000

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Nakano, Joshi, Visnyei, Hu, Watanabe, Lam, Wexler, Saigusa, Nakamura, Laks, Mischel, Viapiano, Kornblum: "Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway." in: Neuro-oncology, Vol. 13, Issue 6, pp. 622-34, (2011) (PubMed).

    Pickard, Green, Ellis, Caldas, Hedge, Mourtada-Maarabouni, Williams: "Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer." in: Breast cancer research : BCR, Vol. 11, Issue 4, pp. R60, (2009) (PubMed).

  • Target
    MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))
    Alternative Name
    MELK (MELK Products)
    Synonyms
    MELK antibody, xmelk antibody, Melk antibody, HPK38 antibody, AI327312 antibody, MPK38 antibody, mKIAA0175 antibody, fb71b01 antibody, fe01f04 antibody, wu:fb71b01 antibody, wu:fe01f04 antibody, maternal embryonic leucine zipper kinase antibody, maternal embryonic leucine zipper kinase L homeolog antibody, MELK antibody, melk antibody, cgd5_2270 antibody, Melk antibody, melk.L antibody
    Background

    Description: Maternal embryonic leucine-zipper kinase (MELK) is a key regulator of survival of stemlike GBM cells in vitro. MELK expression is increased in breast cancer tissue and this increase is also associated with poor patient survival, as predicted for a candidate oncogene.

    Aliases: HPK38

    Molecular Weight
    74.6kDa
    Gene ID
    9833
    HGNC
    9833
    UniProt
    Q14680
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