Lp(a) antibody (AA 1823-2013)

Catalog No. ABIN969533

Product Details anti-Lp(a) Antibody

Target: Lp(a) (Lipoprotein (Lp(a)))

Binding Specificity: AA 1823-2013

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Lp(a) antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purpose: LPA Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human LPA (AA: 1823-2013) expressed in E. Coli.

Clone: 4H1

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Lp(a) antibody (ABIN969533)

Nicholls, Tang, Scoffone, Brennan, Hartiala, Allayee, Hazen: "Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy." in: Journal of lipid research, Vol. 51, Issue 10, pp. 3055-61, (2010) (PubMed).

Rodger, Le Gal, Carrier, Betancourt, Kahn, Wells, Anderson, Lacut, Chagnon, Solymoss, Crowther, Perrier, White, Vickars, Ramsay, Kovacs: "Serum lipoprotein (a) levels in patients with first unprovoked venous thromboembolism is not associated with subsequent risk of recurrent VTE." in: Thrombosis research, Vol. 126, Issue 3, pp. 222-6, (2010) (PubMed).

Target Details for Lp(a)

Target: Lp(a) (Lipoprotein (Lp(a)))

Alternative Name: LPA

Background:

Description: The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence.

Aliases: LP, AK38, APOA

Molecular Weight: 501kDa

Gene ID: 4018

HGNC: 4018

UniProt: P08519