ITGB1 antibody

Catalog No. ABIN969531

Product Details anti-ITGB1 Antibody

Target: ITGB1 (Integrin beta 1 (ITGB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ITGB1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)

Purpose: ITGB1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human ITGB1 expressed in E. Coli.

Clone: 3B6

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-ITGB1 antibody (ABIN969531)

Hamajima, Ozaki, Zhang, Iwane, Kawaguchi, Eguchi, Matsuhashi, Mizuta, Matsuzaki, Fujimoto: "Modulation of the transforming growth factor-beta1-induced Smad phosphorylation by the extracellular matrix receptor beta1-integrin." in: International journal of oncology, Vol. 35, Issue 6, pp. 1441-7, (2009) (PubMed).

Lindberg, Ström, Lock, Gustafsson, Haldosén, Helguero: "Expression of estrogen receptor beta increases integrin alpha1 and integrin beta1 levels and enhances adhesion of breast cancer cells." in: Journal of cellular physiology, Vol. 222, Issue 1, pp. 156-67, (2009) (PubMed).

Target Details for ITGB1

Target: ITGB1 (Integrin beta 1 (ITGB1))

Alternative Name: ITGB1 (ITGB1 Products)

Background:

Description: Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.

Aliases: CD29, FNRB, MDF2, VLAB, GPIIA, MSK12, VLA-BETA

Molecular Weight: 88.4kDa

Gene ID: 3688

HGNC: 3688

UniProt: P05556

Pathways: Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interactome