EIF4B antibody

Catalog No. ABIN969517

Product Details anti-EIF4B Antibody

Target: EIF4B (Eukaryotic Translation Initiation Factor 4B (EIF4B))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EIF4B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: EIF4B Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human EIF4B expressed in E. Coli.

Clone: 1F5

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-EIF4B antibody (ABIN969517)

Mokas, Mills, Garreau, Fournier, Robert, Arya, Kaufman, Pelletier, Mazroui: "Uncoupling stress granule assembly and translation initiation inhibition." in: Molecular biology of the cell, Vol. 20, Issue 11, pp. 2673-83, (2009) (PubMed).

Shahbazian, Roux, Mieulet, Cohen, Raught, Taunton, Hershey, Blenis, Pende, Sonenberg: "The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity." in: The EMBO journal, Vol. 25, Issue 12, pp. 2781-91, (2006) (PubMed).

Target Details for EIF4B

Target: EIF4B (Eukaryotic Translation Initiation Factor 4B (EIF4B))

Alternative Name: EIF4B (EIF4B Products)

Synonyms: EIF-4B antibody, PRO1843 antibody, CG10837 antibody, Dm-eIF4B antibody, Dmel\\CG10837 antibody, Eif4B antibody, eIF-4B-L antibody, eIF-4B-S antibody, eIF-4b antibody, eIF4B antibody, eIF4B-L antibody, eIF4B-S antibody, eIf4b antibody, 2310046H11Rik antibody, AL024095 antibody, C85189 antibody, Eif4a2 antibody, eif4b antibody, fb15c09 antibody, wu:fb15c09 antibody, zgc:101532 antibody, MGC89384 antibody, eukaryotic translation initiation factor 4B antibody, eukaryotic initiation factor 4B antibody, Eukaryotic initiation factor 4B antibody, eukaryotic translation initiation factor 4Bb antibody, eukaryotic translation initiation factor 4Ba antibody, eukaryotic translation initiation factor 4B S homeolog antibody, EIF4B antibody, Eif4B antibody, eIF-4B antibody, Eif4b antibody, eif4bb antibody, eif4b antibody, eif4ba antibody, eif4b.S antibody, LOC100284982 antibody, LOC100380867 antibody

Background:

Description: The eukaryotic translation initiation factor 4B (eIF4B) plays a critical role in recruiting the 40S ribosomal subunit to the mRNA.It functions in close association with eIF4F and eIF4A. It binds near the 5'-terminal cap of mRNA in the presence of eIF4F and ATP. It promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both eIF4A and eIF4F

Aliases: EIF-4B, PRO1843

Molecular Weight: 80kDa

Gene ID: 1975

HGNC: 1975

UniProt: P23588