MATK antibody

Catalog No. ABIN969495

Product Details anti-MATK Antibody

Target: MATK (Megakaryocyte-Associated tyrosine Kinase (MATK))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MATK antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purpose: MATK Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human MATK expressed in E. Coli.

Clone: 9D7

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-MATK antibody (ABIN969495)

McShan, Zagozdzon, Park, Zrihan-Licht, Fu, Avraham, Avraham: "Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration." in: International journal of oncology, Vol. 21, Issue 1, pp. 197-205, (2002) (PubMed).

Target Details for MATK

Target: MATK (Megakaryocyte-Associated tyrosine Kinase (MATK))

Alternative Name: MATK (MATK Products)

Synonyms: si:ch211-63j24.2 antibody, CHK antibody, CTK antibody, HHYLTK antibody, HYL antibody, HYLTK antibody, Lsk antibody, Ntk antibody, Batk antibody, megakaryocyte-associated tyrosine kinase antibody, zinc finger RNA binding protein 2 antibody, matk antibody, MATK antibody, Matk antibody, ZFR2 antibody

Background:

Description: MATK (megakaryocyte-associated tyrosine kinase), also known as CTK, this protein has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.

Aliases: CHK, CTK

Molecular Weight: 56kDa

Gene ID: 4145

HGNC: 4145

UniProt: P42679