TRKA antibody (AA 33-423)
-
- Target See all TRKA (NTRK1) Antibodies
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
-
Binding Specificity
- AA 33-423
-
Reactivity
- Human
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- This TRKA antibody is un-conjugated
-
Application
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
- Purification
- purified
- Immunogen
- Purified recombinant extracellular fragment of human TrkA (aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.
- Clone
- 6B2
- Isotype
- IgG1
- Top Product
- Discover our top product NTRK1 Primary Antibody
-
-
- Application Notes
- ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
-
-
TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent." in: Traffic (Copenhagen, Denmark), Vol. 9, Issue 7, pp. 1146-56, (2008) (PubMed).
: "Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells." in: DNA repair, Vol. 7, Issue 10, pp. 1757-64, (2008) (PubMed).
: "
-
TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent." in: Traffic (Copenhagen, Denmark), Vol. 9, Issue 7, pp. 1146-56, (2008) (PubMed).
-
- Target
- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
- Alternative Name
- TrkA (NTRK1 Products)
- Synonyms
- MTC antibody, TRK antibody, TRK1 antibody, TRKA antibody, Trk-A antibody, p140-TrkA antibody, CDHF12 antibody, CDHR16 antibody, HSCR1 antibody, MEN2A antibody, MEN2B antibody, MTC1 antibody, PTC antibody, RET-ELE1 antibody, RET51 antibody, Trk antibody, C80751 antibody, Tkr antibody, TrkA antibody, trk antibody, trka antibody, CTRKA antibody, trkA antibody, neurotrophic receptor tyrosine kinase 1 antibody, ret proto-oncogene antibody, neurotrophic tyrosine kinase, receptor, type 1 antibody, NTRK1 antibody, RET antibody, Ntrk1 antibody, ntrk1 antibody
- Background
-
Description: TrkA, also known as NTRK1, MTC, TRK, TRK1. It is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Aliases: NTRK1, MTC, TRK, TRK1
- Molecular Weight
- 87.4 kDa
- Gene ID
- 4914
- HGNC
- 4914
- Pathways
- RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
-