TAB2 antibody

Catalog No. ABIN969430

Product Details anti-TAB2 Antibody

Target: TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TAB2 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Purpose: TAB2 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human TAB2 expressed in E. Coli.

Clone: 3B5

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-TAB2 antibody (ABIN969430)

Thienpont, Zhang, Postma, Breckpot, Tranchevent, Van Loo, Møllgård, Tommerup, Bache, Tümer, van Engelen, Menten, Mortier, Waggoner, Gewillig, Moreau, Devriendt, Larsen: "Haploinsufficiency of TAB2 causes congenital heart defects in humans." in: American journal of human genetics, Vol. 86, Issue 6, pp. 839-49, (2010) (PubMed).

Häcker, Karin: "Regulation and function of IKK and IKK-related kinases." in: Science's STKE : signal transduction knowledge environment, Vol. 2006, Issue 357, pp. re13, (2006) (PubMed).

Simmonds, Heward, Carr-Smith, Foxall, Franklyn, Gough: "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease." in: The Journal of clinical endocrinology and metabolism, Vol. 91, Issue 3, pp. 1056-61, (2006) (PubMed).

Target Details for TAB2

Target: TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))

Alternative Name: TAB2 (TAB2 Products)

Synonyms: CHTD2 antibody, MAP3K7IP2 antibody, 1110030N06Rik antibody, A530078N03Rik antibody, Map3k7ip2 antibody, mKIAA0733 antibody, map3k7ip2 antibody, zgc:77446 antibody, TGF-beta activated kinase 1/MAP3K7 binding protein 2 antibody, TAB2 antibody, Tab2 antibody, tab2 antibody

Background:

Description: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.

Aliases: CHTD2, FLJ21885, KIAA0733, MAP3K7IP2, TAB2

Molecular Weight: 80kDa

Gene ID: 23118

HGNC: 23118

UniProt: Q9NYJ8

Pathways: TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway