SUZ12 antibody

Catalog No. ABIN969427

Product Details anti-SUZ12 Antibody

Target: SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SUZ12 antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC)

Purpose: SUZ12 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human SUZ12 expressed in E. Coli.

Clone: 2C11

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-SUZ12 antibody (ABIN969427)

Pasini, Hansen, Christensen, Agger, Cloos, Helin: "Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2." in: Genes & development, Vol. 22, Issue 10, pp. 1345-55, (2008) (PubMed).

Li, Ma, Wang, Koontz, Nucci, Sklar: "Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 50, pp. 20001-6, (2007) (PubMed).

Target Details for SUZ12

Target: SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12))

Alternative Name: SUZ12 (SUZ12 Products)

Background:

Description: This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. (Provided by RefSeq) SUZ12 is overexpressed in several human tumors, including tumors of the colon, breast and liver.Tissue specificity: Overexpressed in breast and colon cancer.

Aliases: CHET9, JJAZ1, KIAA0160, SUZ12

Molecular Weight: 83.1kDa

Gene ID: 23512

HGNC: 23512

UniProt: Q15022