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SLUG antibody

SNAI2 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 2H5 unconjugated
Catalog No. ABIN969410
  • Target See all SLUG (SNAI2) Antibodies
    SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))
    Reactivity
    • 48
    • 17
    • 13
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 38
    • 10
    Mouse
    Clonality
    • 39
    • 8
    Monoclonal
    Conjugate
    • 30
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This SLUG antibody is un-conjugated
    Application
    • 25
    • 18
    • 12
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human SNAI2 expressed in E. coli.
    Clone
    2H5
    Isotype
    IgG1
    Top Product
    Discover our top product SNAI2 Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Saegusa, Hashimura, Kuwata, Okayasu: "Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, (2009) (PubMed).

    Medici, Hay, Olsen: "Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3." in: Molecular biology of the cell, Vol. 19, Issue 11, pp. 4875-87, (2008) (PubMed).

  • Target
    SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))
    Alternative Name
    SNAI2 (SNAI2 Products)
    Synonyms
    Slug antibody, Slugh antibody, Snail2 antibody, snail family transcriptional repressor 2 antibody, snail family zinc finger 2 antibody, Snai2 antibody
    Background

    Description: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in γ-irradiated cells, Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.

    Aliases: SLUG, WS2D, SLUGH1, MGC10182, SNAI2

    Molecular Weight
    30 kDa
    Gene ID
    6591
    HGNC
    6591
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