SNAIL antibody

Catalog No. ABIN969409

Product Details anti-SNAIL Antibody

Target: SNAIL (SNAI1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SNAIL antibody is un-conjugated

Application: ELISA

Purpose: SNAI1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human SNAI1 expressed in E. Coli.

Clone: 6D2

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-SNAIL antibody (ABIN969409)

Wanami, Chen, Peiró, García de Herreros, Bachelder: "Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression." in: Experimental cell research, Vol. 314, Issue 13, pp. 2448-53, (2008) (PubMed).

Herranz, Pasini, Díaz, Francí, Gutierrez, Dave, Escrivà, Hernandez-Muñoz, Di Croce, Helin, García de Herreros, Peiró: "Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor." in: Molecular and cellular biology, Vol. 28, Issue 15, pp. 4772-81, (2008) (PubMed).

Target Details for SNAIL

Target: SNAIL (SNAI1)

Alternative Name: SNAI1 (SNAI1 Products)

Background:

Description: Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.

Aliases: SNA, SNAH, SLUGH2, dJ710H13.1, SNAI1

Molecular Weight: 29kDa

Gene ID: 6615

HGNC: 6615

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling