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RICTOR antibody

RICTOR Reactivity: Human, Mouse, Monkey WB, IHC, ELISA, ICC, FACS Host: Mouse Monoclonal 7B3 unconjugated
Catalog No. ABIN969382
  • Target See all RICTOR Antibodies
    RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))
    Reactivity
    • 57
    • 31
    • 3
    • 1
    • 1
    Human, Mouse, Monkey
    Host
    • 52
    • 5
    • 1
    Mouse
    Clonality
    • 52
    • 6
    Monoclonal
    Conjugate
    • 37
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RICTOR antibody is un-conjugated
    Application
    • 43
    • 31
    • 20
    • 10
    • 8
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human RICTOR expressed in E. coli.
    Clone
    7B3
    Isotype
    IgG1
    Top Product
    Discover our top product RICTOR Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Yang, Inoki, Ikenoue, Guan: "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity." in: Genes & development, Vol. 20, Issue 20, pp. 2820-32, (2006) (PubMed).

  • Target
    RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))
    Alternative Name
    RICTOR (RICTOR Products)
    Synonyms
    PIA antibody, mAVO3 antibody, 4921505C17Rik antibody, 6030405M08Rik antibody, AVO3 antibody, AW492497 antibody, D530039E11Rik antibody, Fyb antibody, RPTOR independent companion of MTOR complex 2 antibody, RPTOR independent companion of MTOR, complex 2 antibody, RICTOR antibody, Rictor antibody
    Background

    Description: Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals . mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, Sin1 and rictor . The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro . This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes . This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR .

    Aliases: PIA, mAVO3, KIAA1999, MGC39830, DKFZp686B11164, RICTOR

    Molecular Weight
    192 kDa
    Gene ID
    253260
    HGNC
    253260
    Pathways
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events
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