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RAG2 antibody (AA 350-527)

RAG2 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 4D5 unconjugated
Catalog No. ABIN969379
  • Target See all RAG2 Antibodies
    RAG2 (Recombination Activating Gene 2 (RAG2))
    Binding Specificity
    • 15
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 350-527
    Reactivity
    • 44
    • 13
    • 13
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 40
    • 5
    Mouse
    Clonality
    • 42
    • 3
    Monoclonal
    Conjugate
    • 21
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RAG2 antibody is un-conjugated
    Application
    • 19
    • 13
    • 13
    • 11
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human RAG2(350-527aa) expressed in E. coli.
    Clone
    4D5
    Isotype
    IgG1
    Top Product
    Discover our top product RAG2 Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Nagawa, Hirose, Nishizumi, Nishihara, Sakano: "Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA." in: The Journal of biological chemistry, Vol. 279, Issue 37, pp. 38360-8, (2004) (PubMed).

  • Target
    RAG2 (Recombination Activating Gene 2 (RAG2))
    Alternative Name
    RAG2 (RAG2 Products)
    Synonyms
    RAG-2 antibody, Rag-2 antibody, rag-2 antibody, zgc:136743 antibody, recombination activating 2 antibody, recombination activating gene 2 antibody, recombination activating gene 2 S homeolog antibody, RAG2 antibody, Rag2 antibody, rag2 antibody, rag2.S antibody
    Background

    Description: This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

    Aliases: RAG-2, RAG2

    Molecular Weight
    59 kDa
    Gene ID
    5897
    HGNC
    5897
    Pathways
    Chromatin Binding, Production of Molecular Mediator of Immune Response
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